Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria
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Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitorsAntiviral L-nucleosides specific for hepatitis B virus infectionCardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudineIn vivo assessment of mitochondrial toxicity of metacavir in Rhesus monkeys after three months of intravenous administration.Tenofovir renal toxicity targets mitochondria of renal proximal tubules.Aging and HIV/AIDS: pathogenetic role of therapeutic side effectsMitochondrial dna depletion, oxidative stress, and mutation: mechanisms of dysfunction from nucleoside reverse transcriptase inhibitors.Anti-HBV specific beta-L-2'-deoxynucleosides.Mitochondria in the pathogenesis of lipodystrophy induced by anti-HIV antiretroviral drugs: actors or bystanders?Phosphorylation of thymidine and AZT in heart mitochondria: elucidation of a novel mechanism of AZT cardiotoxicity3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity.3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria.Evaluation of mitochondrial toxicity in Marmota himalayana treated with metacavir, a novel 2',3'-dideoxyguanosine prodrug for treatment of hepatitis B Virus.Increased plasma gln and Leu Ra and inappropriately low muscle protein synthesis rate in AIDS wasting.Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis.Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopyZidovudine inhibits thymidine phosphorylation in the isolated perfused rat heart.Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.Anthracyclines selectively decrease alpha cardiac actin mRNA abundance in the rat heartAbsence of a universal mechanism of mitochondrial toxicity by nucleoside analogs.Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration.Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondriaAZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stressMitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes.Mitochondrial DNA impairment in nucleoside reverse transcriptase inhibitor-associated cardiomyopathyPharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathyNucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment.Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma.HIV treatment and associated mitochondrial pathology: review of 25 years of in vitro, animal, and human studies.Recent advances in the neurology of HIV infectionHIV, highly active antiretroviral therapy and the heart: a cellular to epidemiological review.Premature and accelerated aging: HIV or HAART?Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood-brain barrier endothelial cells.AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins.Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanismSublethal concentrations of gemcitabine (2',2'-difluorodeoxycytidine) alter mitochondrial ultrastructure and function without reducing mitochondrial DNA content in BxPC-3 human pancreatic carcinoma cells.Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture.Stavudine:pharmacology,clinical use and future role.AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementation.
P2860
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P2860
Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Zidovudine induces molecular, ...... t skeletal muscle mitochondria
@ast
Zidovudine induces molecular, ...... t skeletal muscle mitochondria
@en
type
label
Zidovudine induces molecular, ...... t skeletal muscle mitochondria
@ast
Zidovudine induces molecular, ...... t skeletal muscle mitochondria
@en
prefLabel
Zidovudine induces molecular, ...... t skeletal muscle mitochondria
@ast
Zidovudine induces molecular, ...... t skeletal muscle mitochondria
@en
P2093
P2860
P356
P1476
Zidovudine induces molecular, ...... t skeletal muscle mitochondria
@en
P2093
P2860
P304
P356
10.1172/JCI115722
P407
P577
1992-04-01T00:00:00Z