Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

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Should charge variants of monoclonal antibody therapeutics be considered critical quality attributes?Adsorption Behavior of Charge Isoforms of Monoclonal Antibodies on Strong Cation Exchangers.

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P2860

Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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Charge Variants of an Avastin ...... es and Pharmacokinetics in Rat

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Charge Variants of an Avastin ...... es and Pharmacokinetics in Rat

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Charge Variants of an Avastin ...... es and Pharmacokinetics in Rat

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Charge Variants of an Avastin ...... es and Pharmacokinetics in Rat

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Charge Variants of an Avastin ...... es and Pharmacokinetics in Rat

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Charge Variants of an Avastin ...... es and Pharmacokinetics in Rat

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Charge Variants of an Avastin ...... es and Pharmacokinetics in Rat

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Li-Li Liu

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Ning Wang

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Wan-Hui Liu

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Wen-Jie Tao

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Yan-Yan Zhao

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Zhen-Duo Shen

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P2860

Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

Continuous cultures of fused cells secreting antibody of predefined specificity

Phase I clinical trial of bendamustine and bevacizumab for patients with advanced cancer.

Investigation of degradation processes in IgG1 monoclonal antibodies by limited proteolysis coupled with weak cation-exchange HPLC.

Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc region

Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography.

Separation of oxidized variants of a monoclonal antibody by anion-exchange.

Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.

Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations.

Characterization of the basic charge variants of a human IgG1: effect of copper concentration in cell culture media.

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scholarly article

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10.1371/JOURNAL.PONE.0151874

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English

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2016-03-17T00:00:00Z

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4795741

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Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

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Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

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