Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in ratsSimultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperaturesStructure-based prediction of asparagine and aspartate degradation sites in antibody variable regionsEffect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody.An innovative approach for the characterization of the isoforms of a monoclonal antibody productA new tool for monoclonal antibody analysis: application of IdeS proteolysis in IgG domain-specific characterization.Structural and functional characterization of the trifunctional antibody catumaxomabFragmentation of monoclonal antibodiesDevelopment of a cell-based assay measuring the activation of FcγRIIa for the characterization of therapeutic monoclonal antibodiesCharacterization of the basic charge variants of a human IgG1: effect of copper concentration in cell culture media.Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in RatPurification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography.Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies.At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibodyProteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells.Analytical methods for physicochemical characterization of antibody drug conjugatesQuality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach.Post-translational structural modifications of immunoglobulin G and their effect on biological activity.Ficolin-2 inhibitors are present in sera after prolonged storage at -80 °C.Tailoring recombinant protein quality by rational media design.Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes.Unbiased in-depth characterization of CEX fractions from a stressed monoclonal antibody by mass spectrometry.Impact of cell culture on recombinant monoclonal antibody product heterogeneity.Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry.Effects of carboxypeptidase B treatment and elevated temperature on recombinant monoclonal antibody charge variants in cation-exchange chromatography analysis.Arginine modifications by methylglyoxal: discovery in a recombinant monoclonal antibody and contribution to acidic species.Effect of polysorbate 80 quality on photostability of a monoclonal antibody.Conjugation site heterogeneity causes variable electrostatic properties in Fc conjugates.Discovery of a chemical modification by citric acid in a recombinant monoclonal antibody.Cysteinylation of a monoclonal antibody leads to its inactivation.5th European Antibody Congress 2009: November 30–December 2, 2009, Geneva, Switzerland.4th European Antibody Congress 2008: December 1-3, 2008, Geneva, Switzerland.Effect of polysorbate 80 concentration on thermal and photostability of a monoclonal antibody.Characterization of therapeutic monoclonal antibodies reveals differences between in vitro and in vivo time-course studies.Mass spectrometric distinction of in-source and in-solution pyroglutamate and succinimide in proteins: a case study on rhG-CSF.Avoiding antibody aggregation during processing: establishing hold times.Applications of imaged capillary isoelectric focussing technique in development of biopharmaceutical glycoprotein-based products.Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody.Elucidation of degradants in acidic peak of cation exchange chromatography in an IgG1 monoclonal antibody formed on long-term storage in a liquid formulation.Aggregation and chemical modification of monoclonal antibodies under upstream processing conditions.
P2860
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P2860
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@ast
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@en
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@nl
type
label
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@ast
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@en
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@nl
prefLabel
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@ast
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@en
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@nl
P1476
Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods.
@en
P2093
P304
P356
10.2174/138920108786786402
P577
2008-12-01T00:00:00Z