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SIRT1 activation confers neuroprotection in experimental optic neuritis

SIRT1 activation confers neuroprotection in experimental optic neuritis

http://www.wikidata.org/entity/Q35971418

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Protective effects and mechanisms of sirtuins in the nervous system Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection Mammalian sirtuins: biological insights and disease relevance Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.Mitochondrial disorders and the eye.Resveratrol inhibits neuronal apoptosis and elevated Ca2+/calmodulin-dependent protein kinase II activity in diabetic mouse retina Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.A mechanism of virus-induced demyelination.The Benefits of Calorie Restriction and Calorie Restriction Mimetics as Related to the Eye.Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.Sirt3 protects cortical neurons against oxidative stress via regulating mitochondrial Ca2+ and mitochondrial biogenesis.HE3286 reduces axonal loss and preserves retinal ganglion cell function in experimental optic neuritis.Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis.Axonal degeneration in multiple sclerosis: can we predict and prevent permanent disability?The influence of nutritional factors on the prognosis of multiple sclerosis.Differential expression of sirtuin family members in the developing, adult, and aged rat brain.Interleukin-1β and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene.Oral resveratrol reduces neuronal damage in a model of multiple sclerosis.Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis.Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells.Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system.Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus.Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis.The neuroprotective effect of resveratrol on retinal ganglion cells after optic nerve transection.SIRT1 promotes RGC survival and delays loss of function following optic nerve crush.Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70 The importance of NAD in multiple sclerosis Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis.Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress Sirtuin deacetylases as therapeutic targets in the nervous system SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease In vivo detection of experimental optic neuritis by pupillometry.Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model.Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets

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P2860

SIRT1 activation confers neuroprotection in experimental optic neuritis

http://www.wikidata.org/entity/Q35971418

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

SIRT1 activation confers neuroprotection in experimental optic neuritis

@ast

SIRT1 activation confers neuroprotection in experimental optic neuritis

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type

label

SIRT1 activation confers neuroprotection in experimental optic neuritis

@ast

SIRT1 activation confers neuroprotection in experimental optic neuritis

@en

prefLabel

SIRT1 activation confers neuroprotection in experimental optic neuritis

@ast

SIRT1 activation confers neuroprotection in experimental optic neuritis

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Investigative Ophthalmology & Visual Science

P1476

SIRT1 activation confers neuroprotection in experimental optic neuritis

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P2093

Abdolmohamad Rostami

http://www.w3.org/2001/XMLSchema#string

Elvira Ventura

http://www.w3.org/2001/XMLSchema#string

Kenneth S Shindler

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Peter Elliott

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Tonia S Rex

http://www.w3.org/2001/XMLSchema#string

P2860

Negative control of p53 by Sir2alpha promotes cell survival under stress

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Resveratrol improves health and survival of mice on a high-calorie diet

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3602-3609

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scholarly article

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10.1167/IOVS.07-0131

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8

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48

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2007-08-01T00:00:00Z

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6185525

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17652729

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1964753

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