Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.
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Spatial separation of the cyanogenic β-glucosidase ZfBGD2 and cyanogenic glucosides in the haemolymph of Zygaena larvae facilitates cyanide release.Less effective selection leads to larger genomes.Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by RapamycinThe L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice.Death by over-eating: The Gaucher disease associated gene GBA1, identified in a screen for mediators of autophagic cell death, is necessary for developmental cell death in Drosophila midgut.Mass Histology to Quantify Neurodegeneration in Drosophila.Loss of the Drosophila m-AAA mitochondrial protease paraplegin results in mitochondrial dysfunction, shortened lifespan, and neuronal and muscular degeneration.Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease.Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity.Modeling Parkinson's Disease in Drosophila: What Have We Learned for Dominant Traits?D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model.Lon protease inactivation in causes unfolded protein stress and inhibition of mitochondrial translationGlucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles
P2860
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P2860
Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Glucocerebrosidase Deficiency ...... egation and Neurodegeneration.
@ast
Glucocerebrosidase Deficiency ...... egation and Neurodegeneration.
@en
type
label
Glucocerebrosidase Deficiency ...... egation and Neurodegeneration.
@ast
Glucocerebrosidase Deficiency ...... egation and Neurodegeneration.
@en
prefLabel
Glucocerebrosidase Deficiency ...... egation and Neurodegeneration.
@ast
Glucocerebrosidase Deficiency ...... egation and Neurodegeneration.
@en
P2093
P2860
P1433
P1476
Glucocerebrosidase Deficiency ...... egation and Neurodegeneration.
@en
P2093
Alexandre A Germanos
Brittany N Whitley
Kien Trinh
Leo J Pallanck
Marie Y Davis
Ruth E Thomas
Sergio Pablo Sardi
Thomas J Montine
P2860
P304
P356
10.1371/JOURNAL.PGEN.1005944
P577
2016-03-28T00:00:00Z