Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process. - Wikidata - wikimedia - TriplyDB

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.

http://www.wikidata.org/entity/Q35974133

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New insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptors Interacting influence of diuretics and diet on BK channel-regulated K homeostasis Ubiquitylation and control of renal Na+ balance and blood pressure A molecular update on pseudohypoaldosteronism type II Regulatory roles of nitric oxide and angiotensin II on renal tubular transport Small-molecule WNK inhibition regulates cardiovascular and renal function Renal NCC is unchanged in the midpregnant rat and decreased in the late pregnant rat despite avid renal Na+ retention Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation Primary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney.Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systems Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension.PTH modulation of NCC activity regulates TRPV5 Ca2+ reabsorption.KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1).Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension Regulation of with-no-lysine kinase signaling by Kelch-like proteins.Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.Renin-angiotensin system in the kidney: What is new?WNK4 is the major WNK positively regulating NCC in the mouse kidney Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation Distal convoluted tubule Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2.Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3 Mechanisms of angiotensin II stimulation of NCC are time-dependent in mDCT15 cells.Renal tubule angiotensin II type 1 receptor-associated protein promotes natriuresis and inhibits salt-sensitive blood pressure elevation SPAK-mediated NCC regulation in response to low-K+ diet Aldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway.Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway.Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation.Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties Renal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level.

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P2860

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.

http://www.wikidata.org/entity/Q35974133

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2012 nî lūn-bûn

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Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.

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Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.

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Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.

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Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.

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Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.

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Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.

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Proceedings of the National Academy of Sciences of the United States of America

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Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.

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Alain Doucet

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Luz Graciela Cervantes-Pérez

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Norma A Bobadilla

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Norma Uribe

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Norma Vázquez

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Sheila Kantesaria

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P2860

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

WNK kinases, renal ion transport and hypertension

Human hypertension caused by mutations in WNK kinases

The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

Angiotensin II induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter independent of aldosterone

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109

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María Castañeda-Bueno

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2012-05-01T00:00:00Z

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224879338

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