Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.
about
New insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptorsInteracting influence of diuretics and diet on BK channel-regulated K homeostasisUbiquitylation and control of renal Na+ balance and blood pressureA molecular update on pseudohypoaldosteronism type IIRegulatory roles of nitric oxide and angiotensin II on renal tubular transportSmall-molecule WNK inhibition regulates cardiovascular and renal functionRenal NCC is unchanged in the midpregnant rat and decreased in the late pregnant rat despite avid renal Na+ retentionDisease-causing mutations in KLHL3 impair its effect on WNK4 degradationPrimary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney.Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systemsSympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension.PTH modulation of NCC activity regulates TRPV5 Ca2+ reabsorption.KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1).Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertensionRegulation of with-no-lysine kinase signaling by Kelch-like proteins.Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule.Renin-angiotensin system in the kidney: What is new?WNK4 is the major WNK positively regulating NCC in the mouse kidneyAngiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradationDistal convoluted tubuleChemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2.Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3Mechanisms of angiotensin II stimulation of NCC are time-dependent in mDCT15 cells.Renal tubule angiotensin II type 1 receptor-associated protein promotes natriuresis and inhibits salt-sensitive blood pressure elevationSPAK-mediated NCC regulation in response to low-K+ dietAldosterone modulates thiazide-sensitive sodium chloride cotransporter abundance via DUSP6-mediated ERK1/2 signaling pathway.Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.Alternatively spliced proline-rich cassettes link WNK1 to aldosterone actionA unifying mechanism for WNK kinase regulation of sodium-chloride cotransporterSPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway.Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathwayRegulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation.Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sitesEffects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex propertiesRenal proteinase-activated receptor 2, a new actor in the control of blood pressure and plasma potassium level.
P2860
Q26765204-8DB746C0-9169-483D-B7CC-1A56EAC66C7AQ26824886-748DBB6C-0529-4978-858D-82CF964CCE50Q26863205-A09A2BF4-ED4C-4C2B-AE85-23287A1115EAQ27000474-91939108-027E-4F90-9CEF-3E6B462D94BBQ27012509-997E00D8-F721-45FC-83A9-9C4C0CB6DF9BQ27644248-E92A1EF0-8E68-4891-9114-49A70E43718CQ28397667-75B01639-9993-417F-9B88-59ED7E10F03BQ28771740-529D46FF-2460-4D6B-A646-5EDAD15D425DQ30248429-591404E5-6E1B-453F-AE60-E0B16B7CAF9AQ33660709-A30D982A-41D7-4AD5-9224-8E4C7C517C61Q33770703-D70D2BFE-CAC6-486D-BE89-1895272AEC9BQ34045482-142FE641-9F85-4DBD-904A-B9CEA9653039Q34060743-93BBABA3-63B7-46FC-ADEF-19524C6781CAQ34111828-4A6C49A5-804E-4DAF-A5B4-35A05F79B86CQ34174710-B1654D1E-3CA6-4892-B379-CEA2CFA9070CQ34249011-03651EAE-C46D-4C27-ACF8-59C5AEBD98B4Q34367671-58DBB7A5-DC28-40A9-8420-AE0846ED2874Q34420520-41AEA238-8C36-4E36-9E3B-ADA773E3F716Q34442402-8BFFD202-79B3-40AD-92CF-3159A5150AABQ34629804-CA83FE22-E75D-478B-85CD-ECC8D7E1D5F4Q34974952-F631F32B-AD2A-4C7B-A8E4-9ABFE28F13C5Q34988698-8AF4FC33-96FD-409E-94CB-2C3DFD998B7EQ35086469-7860C0CE-4DBC-44B6-B7E2-68404ADEE678Q35094158-3153ABA9-4A8A-4804-9589-A1DAA560EA80Q35140143-E6330B7E-5166-4441-A602-38098AF40745Q35274077-D013DB0C-B616-4FE0-B548-705E0128379BQ35354119-1CEAA07B-2681-4C17-AAE1-56AFBE69DB2FQ35436934-E0013017-152F-41DE-9BC4-11891C14F9C4Q35622471-F2C2BE11-97A4-45E0-9211-2F8DA96E6D5DQ35790582-2388844D-B55E-49EC-B751-34FC09601CF0Q35900778-329A8889-90E5-48A4-A2F4-D773197C1020Q36106011-2139CFB8-8955-4CCB-802A-F473D91016F4Q36149053-1E0EC832-6A68-4472-BF3A-C2D28DC8BE63Q36368185-51CA6E0C-BF20-4011-A1F3-25BA1B6C918EQ36427915-D8EAC873-AED1-4ABF-8AA4-8AB81F49D962Q36432448-0A218AB4-9127-471F-8291-D0E832BA0EEDQ36494423-BF1472B9-AFE7-49B6-95E3-37294964CE73Q36527855-02F7C1CA-086C-4503-9A5E-67452E247D1DQ36654263-39719F81-9364-4B7C-9373-C5AABC4017EDQ36742129-E2F4ABF5-A031-47B6-8722-B24728A8FB30
P2860
Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.
@ast
Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.
@en
type
label
Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.
@ast
Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.
@en
prefLabel
Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.
@ast
Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.
@en
P2093
P2860
P50
P356
P1476
Activation of the renal Na+:Cl ...... I is a WNK4-dependent process.
@en
P2093
Alain Doucet
Luz Graciela Cervantes-Pérez
Norma A Bobadilla
Norma Uribe
Norma Vázquez
Sheila Kantesaria
P2860
P304
P356
10.1073/PNAS.1200947109
P407
P577
2012-05-01T00:00:00Z