Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
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Disease-causing mutations in KLHL3 impair its effect on WNK4 degradationA novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line.Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathwayRegulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation.Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sitesExtrarenal roles of the with-no-lysine[K] kinases (WNKs).Electroneutral absorption of NaCl by the aldosterone-sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation.Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study.
P2860
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P2860
Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Disease-causing mutations in t ...... f WNK4 kinase to calcium ions.
@ast
Disease-causing mutations in t ...... f WNK4 kinase to calcium ions.
@en
type
label
Disease-causing mutations in t ...... f WNK4 kinase to calcium ions.
@ast
Disease-causing mutations in t ...... f WNK4 kinase to calcium ions.
@en
prefLabel
Disease-causing mutations in t ...... f WNK4 kinase to calcium ions.
@ast
Disease-causing mutations in t ...... f WNK4 kinase to calcium ions.
@en
P2093
P2860
P1476
Disease-causing mutations in t ...... f WNK4 kinase to calcium ions.
@en
P2093
P2860
P304
P356
10.1016/J.BBRC.2012.02.013
P407
P577
2012-02-11T00:00:00Z