Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.
about
Structure of the integral membrane protein CAAX protease Ste24p.Small-molecule inhibitors of the Rce1p CaaX proteaseSte24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides.Chemical inhibition of CaaX protease activity disrupts yeast Ras localization.Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.Isoprenoids, small GTPases and Alzheimer's disease.Photoaffinity labeling of Ras converting enzyme 1 (Rce1p) using a benzophenone-containing peptide substrate.Cell-permeable, small-molecule activators of the insulin-degrading enzyme.Photoaffinity labeling of Ras converting enzyme using peptide substrates that incorporate benzoylphenylalanine (Bpa) residues: improved labeling and structural implications8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.Inhibition of Ras for cancer treatment: the search continues.Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.Heterologous expression studies of Saccharomyces cerevisiae reveal two distinct trypanosomatid CaaX protease activities and identify their potential targets.ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders.Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.The renewed battle against RAS-mutant cancers.Therapeutic strategies for targeting ras proteins.Concepts and advances in cancer therapeutic vulnerabilities in RAS membrane targeting.Rce1: mechanism and inhibition.Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors.Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
P2860
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P2860
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.
@ast
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.
@en
type
label
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.
@ast
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.
@en
prefLabel
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.
@ast
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.
@en
P2093
P2860
P1476
Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.
@en
P2093
David Z Mokry
Emily R Hildebrandt
Sarah R Breevoort
Stephen B Porter
Timothy M Dore
Walter K Schmidt
P2860
P304
P356
10.1016/J.BBAMCR.2007.03.004
P407
P577
2007-03-20T00:00:00Z