Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones. - Wikidata - wikimedia - TriplyDB

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

http://www.wikidata.org/entity/Q35990361

about

Structure of the integral membrane protein CAAX protease Ste24p.Small-molecule inhibitors of the Rce1p CaaX protease Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides.Chemical inhibition of CaaX protease activity disrupts yeast Ras localization.Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.Isoprenoids, small GTPases and Alzheimer's disease.Photoaffinity labeling of Ras converting enzyme 1 (Rce1p) using a benzophenone-containing peptide substrate.Cell-permeable, small-molecule activators of the insulin-degrading enzyme.Photoaffinity labeling of Ras converting enzyme using peptide substrates that incorporate benzoylphenylalanine (Bpa) residues: improved labeling and structural implications 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.Inhibition of Ras for cancer treatment: the search continues.Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.Heterologous expression studies of Saccharomyces cerevisiae reveal two distinct trypanosomatid CaaX protease activities and identify their potential targets.ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders.Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.The renewed battle against RAS-mutant cancers.Therapeutic strategies for targeting ras proteins.Concepts and advances in cancer therapeutic vulnerabilities in RAS membrane targeting.Rce1: mechanism and inhibition.Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors.Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.

P2860

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P2860

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

http://www.wikidata.org/entity/Q35990361

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

@zh

2007年论文

@zh-cn

name

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

@ast

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

@en

type

label

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

@ast

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

@en

prefLabel

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

@ast

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

@en

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J.BBAMCR.2007.03.004

P1433

Biochimica et Biophysica Acta

P1476

Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones.

@en

P2093

David Z Mokry

http://www.w3.org/2001/XMLSchema#string

Emily R Hildebrandt

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Sarah R Breevoort

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Stephen B Porter

http://www.w3.org/2001/XMLSchema#string

Timothy M Dore

http://www.w3.org/2001/XMLSchema#string

Walter K Schmidt

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P2860

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues

Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage

Small-molecule inhibitors of the Rce1p CaaX protease

The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor.

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis.

The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membrane.

Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone.

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853-862

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10.1016/J.BBAMCR.2007.03.004

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6361795

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