Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor
about
Biased and g protein-independent signaling of chemokine receptorsFluorescent approaches for understanding interactions of ligands with G protein coupled receptorsDivergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)Therapeutic Potential of Targeting the Ghrelin Pathway.The potential for selective pharmacological therapies through biased receptor signalingG Protein and β-arrestin signaling bias at the ghrelin receptor.Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptorInhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor.The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelinFrom atomic structures to neuronal functions of g protein-coupled receptorsAgonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor SignalingAdvances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptorPolar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations.Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs.Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response modelLigand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses.Biasing the lipoxin A4/formyl peptide receptor 2 pushes inflammatory resolution.Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor.Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein ActivationNew concepts in pharmacological efficacy at 7TM receptors: IUPHAR review 2.How ligands and signalling proteins affect G-protein-coupled receptors' conformational landscape.GHS-R1a constitutive activity and its physiological relevance.Recent developments in biased agonism.Amphipols in G protein-coupled receptor pharmacology: what are they good for?The mass action equation in pharmacology.Structural mechanism of GPCR-arrestin interaction: recent breakthroughs.In silico Exploration of the Conformational Universe of GPCRs.Signaling bias in drug discovery.Expression, Functional Characterization, and Solid-State NMR Investigation of the G Protein-Coupled GHS Receptor in Bilayer MembranesBiased signalling: from simple switches to allosteric microprocessors.Conformational restriction of G-proteins Coupled Receptors (GPCRs) upon complexation to G-proteins: a putative activation mode of GPCRs?β2-Adrenoceptor-mediated regulation of glucose uptake in skeletal muscle--ligand-directed signalling or a reflection of system complexity?GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia.
P2860
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P2860
Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Ligands and signaling proteins ...... y a G protein-coupled receptor
@ast
Ligands and signaling proteins ...... y a G protein-coupled receptor
@en
type
label
Ligands and signaling proteins ...... y a G protein-coupled receptor
@ast
Ligands and signaling proteins ...... y a G protein-coupled receptor
@en
prefLabel
Ligands and signaling proteins ...... y a G protein-coupled receptor
@ast
Ligands and signaling proteins ...... y a G protein-coupled receptor
@en
P2093
P2860
P356
P1476
Ligands and signaling proteins ...... y a G protein-coupled receptor
@en
P2093
Jacky Marie
Jean-Alain Fehrentz
Jean-Louis Banères
Marjorie Damian
Maxime Louet
Nicolas Floquet
Sophie Mary
P2860
P304
P356
10.1073/PNAS.1119881109
P407
P577
2012-05-09T00:00:00Z