The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
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Structure of an agonist-bound human A2A adenosine receptorAgonist-bound adenosine A2A receptor structures reveal common features of GPCR activationStructure of a nanobody-stabilized active state of the β(2) adrenoceptorInactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimersOpportunities for functional selectivity in GPCR antibodiesCommunication over the network of binary switches regulates the activation of A2A adenosine receptorLigand-specific regulation of the extracellular surface of a G-protein-coupled receptorConserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray CrystallographyStabilized G protein binding site in the structure of constitutively active metarhodopsin-IIG-protein-coupled receptor inactivation by an allosteric inverse-agonist antibodyStructural basis for Smoothened receptor modulation and chemoresistance to anticancer drugsNanobody stabilization of G protein-coupled receptor conformational states.Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsPredicting novel binding modes of agonists to β adrenergic receptors using all-atom molecular dynamics simulationsModulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipidStructure and dynamics of DRD4 bound to an agonist and an antagonist using in silico approaches.Allosteric regulation of G protein-coupled receptor activity by phospholipids.Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Structure-function of the G protein-coupled receptor superfamily.The structural basis of G-protein-coupled receptor signaling (Nobel Lecture)Stability of the neurotensin receptor NTS1 free in detergent solution and immobilized to affinity resinLigand-directed signalling at beta-adrenoceptorsNanobodies to Study G Protein-Coupled Receptor Structure and Function.Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and StabilisationAllosteric sodium in class A GPCR signalingElliptical structure of phospholipid bilayer nanodiscs encapsulated by scaffold proteins: casting the roles of the lipids and the proteinCoupling of g proteins to reconstituted monomers and tetramers of the M2 muscarinic receptorTherapeutic antibodies directed at G protein-coupled receptorsMonomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 bindingNew insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infectionDevelopment and characterization of pepducins as Gs-biased allosteric agonists.Peptide ligand recognition by G protein-coupled receptorsStabilization of G protein-coupled receptors by point mutations.Conformational dynamics of single G protein-coupled receptors in solutionAllosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor MimeticsLigand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor.Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation.Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptorFulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling
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The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 22 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
@en
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
@nl
type
label
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
@en
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
@nl
prefLabel
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
@en
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
@nl
P2093
P2860
P356
P1476
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
@en
P2093
Brian T DeVree
Gisselle Vélez Ruiz
Matthew R Whorton
Roger K Sunahara
Søren G F Rasmussen
Xiao Jie Yao
P2860
P304
P356
10.1073/PNAS.0811437106
P407
P577
2009-05-22T00:00:00Z