DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents. - Wikidata - wikimedia - TriplyDB

DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents.

DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents.

http://www.wikidata.org/entity/Q35996723

about

Eukaryotic DNA polymerase ζ Structure and Functional Analysis of the BRCT Domain of Translesion Synthesis DNA Polymerase Rev1 REV3L, a promising target in regulating the chemosensitivity of cervical cancer cells.Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells.DNA polymerase ζ-dependent lesion bypass in Saccharomyces cerevisiae is accompanied by error-prone copying of long stretches of adjacent DNA.The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity.DNA damage tolerance: a double-edged sword guarding the genome Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypass.REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.Translesion DNA synthesis and mutagenesis in eukaryotes The association of genetic variations in DNA repair pathways with severe toxicities in NSCLC patients undergoing platinum-based chemotherapy.Oxaliplatin in the era of personalized medicine: from mechanistic studies to clinical efficacy.Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival.Minor Groove 3-Deaza-Adenosine Analogues: Synthesis and Bypass in Translesion DNA Synthesis.Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex.Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ.Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.MicroRNA-340 inhibits the proliferation and promotes the apoptosis of colon cancer cells by modulating REV3L.Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells.

P2860

Q27011365-28D039C4-3430-4D25-AB9A-086DE9553F47 Q27675497-4D4ADA05-01B1-4C85-9B97-1F7AA1BD871C Q35190445-18ED7D43-E73D-42AA-9CC5-13DAA04E1B55 Q35377658-CA9855DA-2137-4E35-B4CA-80CD9413C460 Q35590948-2378017D-3FE3-42EF-820F-70A6B3509626 Q35884176-90AC4EB8-4478-4FBE-BC91-4F3191D6E327 Q36626061-8633D7B4-E89F-4527-90E3-298A755A5C82 Q37187991-4967164F-ADBC-45EF-A3B7-1E31CFDDB067 Q37612640-81B313CB-FDC1-4B50-A4AE-A60626EFC78F Q38052100-401E791D-C90B-4837-AE28-5C356329139E Q38063711-89011549-7546-48B9-A315-4059CB61C667 Q38086224-C3E18A6F-D2B7-4C02-9512-DD866D680EF8 Q38632738-F17BFF64-EFD7-4F61-A5E2-CA2C5CCF6680 Q38641139-73BAF28C-33BF-4290-A3F5-2C8FBC8C1B9F Q38751436-60CB675A-411F-430E-991E-A0203A8B5FA4 Q39175014-AE4C4F99-C5B5-4E42-8CA2-979886ECC933 Q39530849-3DFDBECF-95F4-436C-8414-A940EE09E1B9 Q47139347-79AC5F41-DCB8-45B1-BBB6-023AB7738551 Q47209159-8F6565A4-3C5D-485F-81BA-01AF6B005EF7 Q49779139-15FA1915-40B5-4D19-B129-9C1BACEA9595 Q50958792-1C638D28-F04B-4563-92A6-4ED4D25AF71D

P2860

DNA polymerase ζ is a major determinant of resistance to platinum-based chemotherapeutic agents.

http://www.wikidata.org/entity/Q35996723

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

DNA polymerase ζ is a major de ...... based chemotherapeutic agents.

@ast

DNA polymerase ζ is a major de ...... based chemotherapeutic agents.

@en

type

label

DNA polymerase ζ is a major de ...... based chemotherapeutic agents.

@ast

DNA polymerase ζ is a major de ...... based chemotherapeutic agents.

@en

prefLabel

DNA polymerase ζ is a major de ...... based chemotherapeutic agents.

@ast

DNA polymerase ζ is a major de ...... based chemotherapeutic agents.

@en

P1433

Q35996723-008FE984-BCDE-4898-905A-FD9C4DB88296

P1476

Q35996723-3EE84C77-5241-469C-93C8-079A7755A98E

P2093

Q35996723-5FFF6397-8A49-4C0F-851D-7408AA91B9FE

Q35996723-A6580A59-9101-4FF2-B33A-BD3D38F9BCA7

Q35996723-B2E7A663-36BB-43DA-BDA4-BF2130F8FADC

Q35996723-E0404EFA-280B-4B05-8ED1-4854D29691F4

Q35996723-E7D650C5-9EA3-45B4-9860-F79F06ACE129

P2860

Q35996723-0337E550-DC18-4FF7-AC52-FB3F1DF7A453

Q35996723-03A0B1B2-67D1-49BC-B797-F0ABFD4E08EB

Q35996723-060DD61A-7BAD-4E77-8F40-DDADBBDA6073

Q35996723-0C57A58F-9669-45F8-B6DC-B1E7248005AD

Q35996723-1D2F20A7-7566-4C59-91FA-E587837EB0A8

Q35996723-1EE2AFB9-3FE2-4694-8C59-B6C42145686F

Q35996723-23E38D98-04CA-4A64-BF04-816951300483

Q35996723-2B86A44C-A488-4201-9590-B676ED5ECF8B

Q35996723-2E8DF4EE-6B9D-4374-B0C9-E2014FE3776D

Q35996723-2FC5E80E-0AAD-4300-92E6-28CFDC2C42CE

P304

Q35996723-1E7B2852-EBD0-4449-9365-F2698830B635

P31

Q35996723-66CE3157-3BEA-4026-9494-5A01526F3313

P356

Q35996723-537C218E-717D-460D-8EAD-C4F67DC8936F

P433

Q35996723-1413EA3F-1992-48DD-B381-9CC4A7C9D479

P478

Q35996723-B33E3A24-EED2-4F47-AA7B-40802EC49A2B

P577

Q35996723-B70541AC-69C7-4C92-A249-061F31175780

P5875

Q35996723-C9E9907C-F795-4F1A-AF86-9D3419E37F46

P698

Q35996723-B103ADE7-38F6-4BF9-A51C-317409631B67

P921

Q35996723-53CCE4F8-6BDD-40F7-8FD0-251AFE2047AA

P932

Q35996723-F9A1C3E4-1110-405F-9896-E1C23D7F8D57

P356

P1433

Molecular Pharmacology

P1476

DNA polymerase ζ is a major de ...... based chemotherapeutic agents.

@en

P2093

Ariell M Joiner

http://www.w3.org/2001/XMLSchema#string

Christine E Canman

http://www.w3.org/2001/XMLSchema#string

Katelyn H Roberts

http://www.w3.org/2001/XMLSchema#string

Nicholas A Shah

http://www.w3.org/2001/XMLSchema#string

Shilpy Sharma

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2

Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents

Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest

Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy

Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance

Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta

Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links

REV1 and polymerase ζ facilitate homologous recombination repair

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

P304

778-787

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1124/MOL.111.076828

http://www.w3.org/2001/XMLSchema#string

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

81

http://www.w3.org/2001/XMLSchema#string

P577

2012-03-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221885681

http://www.w3.org/2001/XMLSchema#string

P698

22387291

http://www.w3.org/2001/XMLSchema#string

P921

P932

3362893

http://www.w3.org/2001/XMLSchema#string