Raf kinases: function, regulation and role in human cancer. - Wikidata - wikimedia - TriplyDB

Raf kinases: function, regulation and role in human cancer.

Raf kinases: function, regulation and role in human cancer.

http://www.wikidata.org/entity/Q36002845

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FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies Raf family kinases: old dogs have learned new tricks Human pyruvate kinase M2: a multifunctional protein Noonan syndrome Molecular pathology of lung cancer: key to personalized medicine.Long non-coding RNA regulation of epithelial-mesenchymal transition in cancer metastasis An overview on the role of dietary phenolics for the treatment of cancers FAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistance Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis.Overexpression of Raf-1 and ERK1/2 in sacral chordoma and association with tumor recurrence.HER2-positive breast cancer cells expressing elevated FAM83A are sensitive to FAM83A loss.A genetic screen for anchorage-independent proliferation in mammalian cells identifies a membrane-bound neuregulin.From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.Conserved genes act as modifiers of invertebrate SMN loss of function defects Noonan syndrome: clinical aspects and molecular pathogenesis.Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma.Noonan syndrome and clinically related disorders.Cell fate decisions are specified by the dynamic ERK interactome.Transgenic plants as low-cost platform for chemotherapeutic drugs screening Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation.Phospholipase D: enzymology, functionality, and chemical modulation β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway Mechanism of QHF-cisplatin against hepatocellular carcinoma in a mouse model.Essential roles of Raf/extracellular signal-regulated kinase/mitogen-activated protein kinase pathway, YY1, and Ca2+ influx in growth arrest of human vascular smooth muscle cells by bilirubin 2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy.Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants Functional screen identifies kinases driving prostate cancer visceral and bone metastasis.Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.MEK-1 activates C-Raf through a Ras-independent mechanism.Role of raf-1 kinase in diabetes-induced accelerated apoptosis of retinal capillary cells.Selective Raf inhibition in cancer therapy.Role of B-Raf(V600E) in differentiated thyroid cancer and preclinical validation of compounds against B-Raf(V600E).Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules.Heparan sulfate proteoglycans: structure, protein interactions and cell signaling.Validation of a network-based strategy for the optimization of combinatorial target selection in breast cancer therapy: siRNA knockdown of network targets in MDA-MB-231 cells as an in vitro model for inhibition of tumor development.

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P2860

Raf kinases: function, regulation and role in human cancer.

http://www.wikidata.org/entity/Q36002845

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2007 nî lūn-bûn

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Raf kinases: function, regulation and role in human cancer.

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Raf kinases: function, regulation and role in human cancer.

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Raf kinases: function, regulation and role in human cancer.

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Alexander Kaplun

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Deborah T Leicht

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Guri Tzivion

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Ludmila Kaplun

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Melissa Dobson

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Vinita Singh-Gupta

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Vitaly Balan

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P2860

CNK, a RAF-binding multidomain protein required for RAS signaling

Second nature: biological functions of the Raf-1 "kinase"

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

KSR, a novel protein kinase required for RAS signal transduction

Endothelial apoptosis in Braf-deficient mice

Bcl-2 targets the protein kinase Raf-1 to mitochondria

Back to the roots: the remarkable RAF oncogene story

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation

Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation

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