Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome. - Wikidata - wikimedia - TriplyDB

Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome.

Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome.

http://www.wikidata.org/entity/Q36014935

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MicroRNA-277 modulates the neurodegeneration caused by Fragile X premutation rCGG repeats Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI)Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS Fragile X spectrum disorders Cytosine modifications in neurodevelopment and diseases Fragile X-associated tremor/ataxia syndrome.The multiple molecular facets of fragile X-associated tremor/ataxia syndrome Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Neuronal RNA-binding proteins in health and disease RNA-mediated neurodegeneration in fragile X-associated tremor/ataxia syndrome Unstable mutations in the FMR1 gene and the phenotypes Repeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disorders The unstable repeats--three evolving faces of neurological disease X-ray structure of Pur- reveals a Whirly-like fold and an unusual nucleic-acid binding surface A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.Modeling diseases of noncoding unstable repeat expansions using mutant pluripotent stem cells.Genetic and chemical modifiers of a CUG toxicity model in Drosophila CGG Repeats in the 5'UTR of FMR1 RNA Regulate Translation of Other RNAs Localized in the Same RNA Granules PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats RNA and disease C. elegans pur alpha, an activator of end-1, synergizes with the Wnt pathway to specify endoderm.CGG repeat in the FMR1 gene: size matters Computational investigation of RNA CUG repeats responsible for myotonic dystrophy 1 Fibroblast phenotype in male carriers of FMR1 premutation alleles Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells.Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.Evidence for RNA-mediated toxicity in the fragile X-associated tremor/ataxia syndrome.Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons.RNA metabolism in neurodegenerative disease.Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.Long tract of untranslated CAG repeats is deleterious in transgenic mice Advances in understanding the molecular basis of FXTAS SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.Nuclear accumulation of stress response mRNAs contributes to the neurodegeneration caused by Fragile X premutation rCGG repeats Approaches to identify genetic variants that influence the risk for onset of fragile X-associated primary ovarian insufficiency (FXPOI): a preliminary study.Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome Fragile X and autism: Intertwined at the molecular level leading to targeted treatments.RNA-protein interactions in unstable microsatellite diseases.Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathology Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration

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P2860

Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome.

http://www.wikidata.org/entity/Q36014935

description

2007 nî lūn-bûn

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Pur alpha binds to rCGG repeat ...... gile X tremor/ataxia syndrome.

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Pur alpha binds to rCGG repeat ...... gile X tremor/ataxia syndrome.

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Pur alpha binds to rCGG repeat ...... gile X tremor/ataxia syndrome.

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Pur alpha binds to rCGG repeat ...... gile X tremor/ataxia syndrome.

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Pur alpha binds to rCGG repeat ...... gile X tremor/ataxia syndrome.

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Pur alpha binds to rCGG repeat ...... agile X tremor/ataxia syndrome

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Abrar Qurashi

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Donghua Tian

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Huijie Liu

http://www.w3.org/2001/XMLSchema#string

Peng Jin

http://www.w3.org/2001/XMLSchema#string

Ranhui Duan

http://www.w3.org/2001/XMLSchema#string

Stephen T Warren

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Tracie C Rosser

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Yunlong Qin

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P2860

Recruitment of human muscleblind proteins to (CUG)(n) expansions associated with myotonic dystrophy

Purification of nuclear proteins from human HeLa cells that bind specifically to the unstable tandem repeat (CGG)n in the human FMR1 gene

Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy

Puralpha: a multifunctional single-stranded DNA- and RNA-binding protein

Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation

The fragile-X premutation: a maturing perspective.

RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1

Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor

The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome

A muscleblind knockout model for myotonic dystrophy

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