Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome. - Wikidata - wikimedia - TriplyDB

Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.

Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.

http://www.wikidata.org/entity/Q33775485

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Transcriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X Syndrome Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders Fragile X spectrum disorders Repeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disorders Histone deacetylases and their role in motor neuron degeneration The promise and perils of HDAC inhibitors in neurodegeneration Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice.CGG repeat in the FMR1 gene: size matters Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells Fragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism Fragile x-associated tremor ataxia syndrome: the expanding clinical picture, pathophysiology, epidemiology, and update on treatment.Fragile X mental retardation protein expression in Alzheimer's disease Activation of mTOR ameliorates fragile X premutation rCGG repeat-mediated neurodegeneration A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.Bromodomain inhibitors regulate the C9ORF72 locus in ALS Repeat-mediated epigenetic dysregulation of the FMR1 gene in the fragile X-related disorders.RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome Chromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia.Impaired activity-dependent FMRP translation and enhanced mGluR-dependent LTD in Fragile X premutation mice Neurodegeneration the RNA way Epigenetics in nucleotide repeat expansion disorders.Essential role of HDAC6 in the regulation of PD-L1 in melanoma.RNA-mediated toxicity in neurodegenerative disease Epigenetics, autism spectrum, and neurodevelopmental disorders.Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood.Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1.Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases Mechanisms of toxicity in C9FTLD/ALS.RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity.Chromatin regulators in neurodevelopment and disease: Analysis of fly neural circuits provides insights: Networks of chromatin regulators and transcription factors underlie Drosophila neurogenesis and cognitive defects in intellectual disability and Development of Therapeutics for C9ORF72 ALS/FTD-Related Disorders.TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse.CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome.Recent advances in assays for the fragile X-related disorders.Repeat-associated non-AUG (RAN) translation and other molecular mechanisms in Fragile X Tremor Ataxia Syndrome.splice variant: A predictor of fragile X-associated tremor/ataxia syndrome

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P2860

Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.

http://www.wikidata.org/entity/Q33775485

description

2010 nî lūn-bûn

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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Histone deacetylases suppress ...... gile X tremor ataxia syndrome.

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Histone deacetylases suppress ...... gile X tremor ataxia syndrome.

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type

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Histone deacetylases suppress ...... gile X tremor ataxia syndrome.

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Histone deacetylases suppress ...... gile X tremor ataxia syndrome.

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Histone deacetylases suppress ...... gile X tremor ataxia syndrome.

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Histone deacetylases suppress ...... gile X tremor ataxia syndrome.

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Histone deacetylases suppress ...... agile X tremor ataxia syndrome

@en

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Amy Krans

http://www.w3.org/2001/XMLSchema#string

Henry L Paulson

http://www.w3.org/2001/XMLSchema#string

Nicholas A Di Prospero

http://www.w3.org/2001/XMLSchema#string

Peter K Todd

http://www.w3.org/2001/XMLSchema#string

Seok Yoon Oh

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Udai B Pandey

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P2860

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex

The fragile-X premutation: a maturing perspective.

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection

The language of covalent histone modifications

Penetrance of the fragile X-associated tremor/ataxia syndrome in a premutation carrier population

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

Functions of site-specific histone acetylation and deacetylation

A mouse model of the human Fragile X syndrome I304N mutation.

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21170301

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3000359

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