Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).
about
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencyDiscovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compoundAcyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.
P2860
Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Tetrahydronaphthyridine and di ...... glutamate receptor 5 (mGlu₅).
@ast
Tetrahydronaphthyridine and di ...... glutamate receptor 5 (mGlu₅).
@en
type
label
Tetrahydronaphthyridine and di ...... glutamate receptor 5 (mGlu₅).
@ast
Tetrahydronaphthyridine and di ...... glutamate receptor 5 (mGlu₅).
@en
prefLabel
Tetrahydronaphthyridine and di ...... glutamate receptor 5 (mGlu₅).
@ast
Tetrahydronaphthyridine and di ...... glutamate receptor 5 (mGlu₅).
@en
P2093
P2860
P50
P356
P1476
Tetrahydronaphthyridine and di ...... glutamate receptor 5 (mGlu₅).
@en
P2093
C David Weaver
Carrie K Jones
Chrysa Malosh
Claire Mackie
Elizabeth J Herman
Gregor J MacDonald
Han Min Tong
Hilde Lavreysen
J Scott Daniels
Jason T Manka
P2860
P304
P356
10.1021/JM500259Z
P407
P577
2014-06-25T00:00:00Z