Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy.
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Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channelsStructural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding DomainSolution structure of the Mesorhizobium loti K1 channel cyclic nucleotide-binding domain in complex with cAMPStructural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelStructural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channelUnstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activationA Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMPDeterminants of ligand selectivity in a cyclic nucleotide–regulated potassium channelIdentification of putative potassium channel homologues in pathogenic protozoaAbsence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methodsDouble electron-electron resonance reveals cAMP-induced conformational change in HCN channels.The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channelStructural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMPStructure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides.Effects of surface water on protein dynamics studied by a novel coarse-grained normal mode approach.Pathway and endpoint free energy calculations for cyclic nucleotide binding to HCN channels.Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides.A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channelsCNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactionsTRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.Flavonoid regulation of HCN2 channels.Cyclic nucleotide-regulated cation channels.Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMPBuilding KCNQ1/KCNE1 channel models and probing their interactions by molecular-dynamics simulations.New perspectives in cyclic nucleotide-mediated functions in the CNS: the emerging role of cyclic nucleotide-gated (CNG) channels.Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b.Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity.Structure of a eukaryotic cyclic-nucleotide-gated channel.Normal-mode-analysis-guided investigation of crucial intersubunit contacts in the cAMP-dependent gating in HCN channels.Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance.State-dependent cAMP binding to functioning HCN channels studied by patch-clamp fluorometry.Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2.Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia
P2860
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P2860
Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Gating of HCN channels by cycl ...... ng, selectivity, and efficacy.
@ast
Gating of HCN channels by cycl ...... ng, selectivity, and efficacy.
@en
type
label
Gating of HCN channels by cycl ...... ng, selectivity, and efficacy.
@ast
Gating of HCN channels by cycl ...... ng, selectivity, and efficacy.
@en
prefLabel
Gating of HCN channels by cycl ...... ng, selectivity, and efficacy.
@ast
Gating of HCN channels by cycl ...... ng, selectivity, and efficacy.
@en
P2860
P1433
P1476
Gating of HCN channels by cycl ...... ng, selectivity, and efficacy.
@en
P2093
Steven A Siegelbaum
P2860
P304
P356
10.1016/J.STR.2007.04.012
P577
2007-06-01T00:00:00Z