Increased motion and travel, rather than stable docking, characterize the last moments before secretory granule fusion.
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Munc18/Syntaxin interaction kinetics control secretory vesicle dynamics.Loose coupling between calcium channels and sites of exocytosis in chromaffin cellsDistinct initial SNARE configurations underlying the diversity of exocytosisDocking of LDCVs is modulated by lower intracellular [Ca2+] than primingThe F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.Granuphilin exclusively mediates functional granule docking to the plasma membrane.Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulationVesicle fusion probability is determined by the specific interactions of munc18Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle poolVesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodiesAn endosomal tether undergoes an entropic collapse to bring vesicles together.Modulating vesicle priming reveals that vesicle immobilization is necessary but not sufficient for fusion-competence.Localized topological changes of the plasma membrane upon exocytosis visualized by polarized TIRFM.Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.Mapping dynamic protein interactions to insulin secretory granule behavior with TIRF-FRET.Secretory vesicles are preferentially targeted to areas of low molecular SNARE densityMunc13-4 restricts motility of Rab27a-expressing vesicles to facilitate lipopolysaccharide-induced priming of exocytosis in neutrophilsSpatiotemporal detection and analysis of exocytosis reveal fusion "hotspots" organized by the cytoskeleton in endocrine cells.Observations of calcium dynamics in cortical secretory vesicles.Signaling for vesicle mobilization and synaptic plasticity.Navigation through the Plasma Membrane Molecular Landscape Shapes Random Organelle MovementImaging large cohorts of single ion channels and their activity.Exocytosis through the LensMolecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.Observer-independent quantification of insulin granule exocytosis and pre-exocytotic mobility by TIRF microscopy.Mathematical modeling of insulin secretion and the role of glucose-dependent mobilization, docking, priming and fusion of insulin granules.Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules.Bidirectional insulin granule turnover in the submembrane space during K(+) depolarization-induced secretion.
P2860
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P2860
Increased motion and travel, rather than stable docking, characterize the last moments before secretory granule fusion.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Increased motion and travel, r ...... fore secretory granule fusion.
@ast
Increased motion and travel, r ...... fore secretory granule fusion.
@en
type
label
Increased motion and travel, r ...... fore secretory granule fusion.
@ast
Increased motion and travel, r ...... fore secretory granule fusion.
@en
prefLabel
Increased motion and travel, r ...... fore secretory granule fusion.
@ast
Increased motion and travel, r ...... fore secretory granule fusion.
@en
P2093
P2860
P356
P1476
Increased motion and travel, r ...... fore secretory granule fusion.
@en
P2093
Daniel Axelrod
Miriam W Allersma
Ronald W Holz
Vadim E Degtyar
P2860
P304
15929-15934
P356
10.1073/PNAS.0705406104
P407
P577
2007-09-24T00:00:00Z