Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas - Wikidata - wikimedia - TriplyDB

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

http://www.wikidata.org/entity/Q36026392

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Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data Targeting the PI3K signaling pathway in cancer Intrinsic resistance to EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer with activating EGFR mutations Regulation of Bim in Health and Disease The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: challenges and perspectives Apoptotic agents Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers.A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis PharmGKB summary: very important pharmacogene information for the epidermal growth factor receptor High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)The conformational control inhibitor of tyrosine kinases DCC-2036 is effective for imatinib-resistant cells expressing T674I FIP1L1-PDGFRα Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia The intersection between DNA damage response and cell death pathways Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents An unbiased metric of antiproliferative drug effect in vitro.Why do cancer cells become "addicted" to oncogenic epidermal growth factor receptor?High BIM mRNA levels are associated with longer survival in advanced gastric cancer Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β Amphiregulin promotes BAX inhibition and resistance to gefitinib in non-small-cell lung cancers.Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells.Role for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell line Gene profiling of MTA1 identifies novel gene targets and functions.PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells Clinical significance of BIM deletion polymorphism in non-small-cell lung cancer with epidermal growth factor receptor mutation.ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells.Expression of Bim, Noxa, and Puma in non-small cell lung cancer EGFR-mutated lung cancer: a paradigm of molecular oncology.Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer.

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Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

http://www.wikidata.org/entity/Q36026392

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2007 nî lūn-bûn

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Induction of BIM is essential ...... dependent lung adenocarcinomas

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Induction of BIM is essential ...... dependent lung adenocarcinomas

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Induction of BIM is essential ...... dependent lung adenocarcinomas

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Induction of BIM is essential ...... dependent lung adenocarcinomas

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Induction of BIM is essential ...... dependent lung adenocarcinomas

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Induction of BIM is essential ...... dependent lung adenocarcinomas

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Induction of BIM is essential ...... dependent lung adenocarcinomas

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Marissa Balak

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Romel Somwar

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Xuejun Jiang

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Yixuan Gong

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P2860

PUMA induces the rapid apoptosis of colorectal cancer cells

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

Bim: a novel member of the Bcl-2 family that promotes apoptosis

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

Movement of Bax from the cytosol to mitochondria during apoptosis

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

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