bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. - Wikidata - wikimedia - TriplyDB

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis.

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis.

http://www.wikidata.org/entity/Q36040551

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Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)Noxa in colorectal cancer: a study on DNA, mRNA and protein expression PUMA mediates the apoptotic response to p53 in colorectal cancer cells PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members Association of Ubc9, an E2 ligase for SUMO conjugation, with p53 is regulated by phosphorylation of p53 Zinc oxide nanoparticles-induced epigenetic change and G2/M arrest are associated with apoptosis in human epidermal keratinocytes Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system Integral role of Noxa in p53-mediated apoptotic response Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes.Impaired BAX protein expression in breast cancer: mutational analysis of the BAX and the p53 gene.Analysis of p53/BAX in primary colorectal carcinoma: low BAX protein expression is a negative prognostic factor in UICC stage III tumors.Multigene analysis of Rb pathway and apoptosis control in esophageal squamous cell carcinoma identifies patients with good prognosis.Sharp-1 modulates the cellular response to DNA damage.Induction of p53, p21 and apoptosis by silencing the NF90/NF45 complex in human papilloma virus-transformed cervical carcinoma cells.The p53 pathway and apoptosis.Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest Regulation of Mdm2-directed degradation by the C terminus of p53.Apoptosis in cancer.Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines.Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.Mechanisms of cell-cycle checkpoints: at the crossroads of carcinogenesis and drug discovery.Nuclear and mitochondrial apoptotic pathways of p53.p400 is required for E1A to promote apoptosis.Dysregulation of apoptosis and a novel mechanism of defective apoptotic signal transduction in human B-cell neoplasms.Grape seed proanthocyanidins induce apoptosis through p53, Bax, and caspase 3 pathways.Simian virus 40 large T antigen and two independent T-antigen segments sensitize cells to apoptosis following genotoxic damage BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901.Two novel determinants of etoposide resistance in small cell lung cancer.PML is induced by oncogenic ras and promotes premature senescence E1A signaling to p53 involves the p19(ARF) tumor suppressor.

P2860

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P2860

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis.

http://www.wikidata.org/entity/Q36040551

description

1997 nî lūn-bûn

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1997年の論文

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1997年学术文章

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1997年学术文章

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1997年学术文章

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1997年学术文章

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1997年学术文章

@zh-sg

1997年學術文章

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1997年學術文章

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1997年學術文章

@zh-hant

name

bax-deficiency promotes drug r ...... ating p53-dependent apoptosis.

@ast

bax-deficiency promotes drug r ...... ating p53-dependent apoptosis.

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type

label

bax-deficiency promotes drug r ...... ating p53-dependent apoptosis.

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bax-deficiency promotes drug r ...... ating p53-dependent apoptosis.

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prefLabel

bax-deficiency promotes drug r ...... ating p53-dependent apoptosis.

@ast

bax-deficiency promotes drug r ...... ating p53-dependent apoptosis.

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

bax-deficiency promotes drug r ...... ating p53-dependent apoptosis.

@en

P2093

C M Knudson

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M E McCurrach

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S J Korsmeyer

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S W Lowe

http://www.w3.org/2001/XMLSchema#string

T M Connor

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P2860

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression.

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

Production of high-titer helper-free retroviruses by transient transfection

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Tumor spectrum analysis in p53-mutant mice

P304

2345-2349

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10.1073/PNAS.94.6.2345

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6

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94

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14096523

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9122197

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P921

apoptotic process

P932

20090

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