Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia - Wikidata - wikimedia - TriplyDB

Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia

Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia

http://www.wikidata.org/entity/Q36051353

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Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes Biliary atresia: cellular dynamics and immune dysregulation Identification of a plant isoflavonoid that causes biliary atresia B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia.Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-γ/STAT1 pathway.Biliary atresia: will blocking inflammation tame the disease?Staging of biliary atresia at diagnosis by molecular profiling of the liver Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2.Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2/Cxcl2.Generation of a cholangiocyte-specific cDNA expression library for the identification of B and T cell autoantigens in murine biliary disease.RRAS: A key regulator and an important prognostic biomarker in biliary atresia.Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia.HMGB1-promoted and TLR2/4-dependent NK cell maturation and activation take part in rotavirus-induced murine biliary atresia.Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype.Natural killer cells promote long-term hepatobiliary inflammation in a low-dose rotavirus model of experimental biliary atresia MicroRNA profiling identifies miR-29 as a regulator of disease-associated pathways in experimental biliary atresia What Causes Biliary Atresia? Unique Aspects of the Neonatal Immune System Provide Clues to Disease Pathogenesis Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells.Rhesus rotavirus VP4 sequence-specific activation of mononuclear cells is associated with cholangiopathy in murine biliary atresia.Role of CD56-expressing immature biliary epithelial cells in biliary atresia Lack of HLA predominance and HLA shared epitopes in biliary Atresia Rotavirus replication in the cholangiocyte mediates the temporal dependence of murine biliary atresia.Aetiology of biliary atresia: what is actually known?α-enolase autoantibodies cross-reactive to viral proteins in a mouse model of biliary atresia.Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia.Clues to the etiology of bile duct injury in biliary atresia Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia.Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles.Biliary atresia: Where do we stand now?Biliary atresia: a new immunological insight into etiopathogenesis.Advances in biliary atresia: from patient care to research.Liver fibrosis in biliary atresia.Current options for management of biliary atresia.Recent Advances in Etiology of Biliary Atresia.Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates.Dendritic cells regulate natural killer cell activation and epithelial injury in experimental biliary atresia.Temporal-spatial activation of apoptosis and epithelial injury in murine experimental biliary atresia.Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia.Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia.Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia.

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Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia

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Claire Chougnet

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Gregg Sabla

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P2860

Identification, genomic organization, chromosomal mapping and mutation analysis of the human INV gene, the ortholog of a murine gene implicated in left-right axis development and biliary atresia.

CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice

Development of neonatal Th1/Th2 function.

T cell immunity in neonates.

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

Pathogenesis and outcome of biliary atresia: current concepts.

Role of B cells and cytotoxic T lymphocytes in clearance of and immunity to rotavirus infection in mice.

Evidence that resolution of rotavirus infection in mice is due to both CD4 and CD8 cell-dependent activities

Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation

Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia.

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