EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
about
Complex or monosomal karyotype and not blast percentage is associated with poor survival in acute myeloid leukemia and myelodysplastic syndrome patients with inv(3)(q21q26.2)/t(3;3)(q21;q26.2): a Bone Marrow Pathology Group studyGlobal Identification of EVI1 Target Genes in Acute Myeloid Leukemia.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology GroupClinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors.Cell of origin determines clinically relevant subtypes of MLL-rearranged AMLEVI1 Interferes with Myeloid Maturation via Transcriptional Repression of Cebpa, via Binding to Two Far Downstream Regulatory Elements.Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation.EVI1 expression in childhood acute lymphoblastic leukaemia is not restricted to MLL and BCR/ABL rearrangements and is influenced by age.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.In focus: MLL-rearranged leukemia.Mechanisms of mixed-lineage leukemia.EVI1 promotes tumor growth via transcriptional repression of MS4A3.Review: Aberrant EVI1 expression in acute myeloid leukaemia.Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia.CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo.Aberrant expression of ecotropic viral integration site-1 in acute myeloid leukemia and acute lymphoblastic leukemia.EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia.
P2860
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P2860
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
@ast
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
@en
type
label
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
@ast
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
@en
prefLabel
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
@ast
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
@en
P2093
P2860
P1433
P1476
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs
@en
P2093
Andrei V Krivtsov
Ashish R Kumar
Claudia Erpelinck
Elizabeth Wocjtowicz
Elwin Rombouts
Eric M J Bindels
H Berna Beverloo
Hartmut Döhner
John H Kersey
Marije Havermans
P2860
P304
P356
10.1182/BLOOD-2011-11-393827
P407
P577
2012-05-02T00:00:00Z