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Brain-penetrant LSD1 inhibitors can block memory consolidation.

Brain-penetrant LSD1 inhibitors can block memory consolidation.

http://www.wikidata.org/entity/Q36057705

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Epigenetic Regulation of Oxidative Stress in Ischemic Stroke Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells Epigenetic mechanisms in mood disorders: targeting neuroplasticity KDM1 class flavin-dependent protein lysine demethylases LSD1 Histone Demethylase Assays and Inhibition Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation.PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition Epigenetic memory: the Lamarckian brain Targeting histone lysine demethylases - progress, challenges, and the future Epigenetic mechanisms of memory formation and reconsolidation.Environmental enrichment reverses histone methylation changes in the aged hippocampus and restores age-related memory deficits.The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch.Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1 3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.DNA methylation and childhood maltreatment: from animal models to human studies.An overview of phenylcyclopropylamine derivatives: biochemical and biological significance and recent developments.Histone lysine demethylases as targets for anticancer therapy.Epigenetic molecular recognition: a biomolecular modeling perspective.KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.Inhibitors of Protein Methyltransferases and Demethylases.Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy.Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.Epigenetic regulation of cognition: A circumscribed review of the field.Histone Lysine Demethylase Inhibitors.Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties.Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.Epigenetic mechanisms in learning and memory.The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).Exogenous application of histone demethylase inhibitor trans-2-phenylcyclopropylamine mimics FLD loss-of-function phenotype in terms of systemic acquired resistance in Arabidopsis thaliana.A selective phenelzine analogue inhibitor of histone demethylase LSD1.Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines.3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors.Adolescent alcohol exposure alters lysine demethylase 1 (LSD1) expression and histone methylation in the amygdala during adulthood.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.

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Brain-penetrant LSD1 inhibitors can block memory consolidation.

http://www.wikidata.org/entity/Q36057705

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2011 nî lūn-bûn

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2011年の論文

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2011年论文

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Brain-penetrant LSD1 inhibitors can block memory consolidation.

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Brain-penetrant LSD1 inhibitors can block memory consolidation.

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Brain-penetrant LSD1 inhibitors can block memory consolidation.

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Brain-penetrant LSD1 inhibitors can block memory consolidation.

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Brain-penetrant LSD1 inhibitors can block memory consolidation.

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ACS Chemical Neuroscience

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Brain-penetrant LSD1 inhibitors can block memory consolidation

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P2093

Emily L Ricq

http://www.w3.org/2001/XMLSchema#string

Ian T Hill

http://www.w3.org/2001/XMLSchema#string

Marcelo A Wood

http://www.w3.org/2001/XMLSchema#string

Melissa Malvaez

http://www.w3.org/2001/XMLSchema#string

Ramesh Neelamegam

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Stephanie Norton

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Stephen M Carlin

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P2860

Structural basis of LSD1-CoREST selectivity in histone H3 recognition

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Histone methylation regulates memory formation.

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

The language of covalent histone modifications

Chromatin modifications and their function

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120-128

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10.1021/CN200104Y

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2

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3

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Stephen J Haggarty

Jacob M. Hooker

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2011-10-18T00:00:00Z

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228106381

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22754608

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3382965

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