Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.

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LSD1 Histone Demethylase Assays and Inhibition Advances toward LSD1 inhibitors for cancer therapy.Inhibitors of Protein Methyltransferases and Demethylases.C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors.

P2860

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P2860

Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.

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http://www.wikidata.org/entity/Q38662691

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.

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type

Item

label

Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.

@en

prefLabel

Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.

@en

P1476

Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.

@en

P2093

Boshi Huang

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Peng Zhan

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Takayoshi Suzuki

http://www.w3.org/2001/XMLSchema#string

Xueshun Wang

http://www.w3.org/2001/XMLSchema#string

P2860

The emerging role of histone lysine demethylases in prostate cancer

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A

Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer

The histone LSD1 demethylase in stemness and cancer transcription programs

Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer

Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin

Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells

P304

1379-1396

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scholarly article

P356

10.2217/EPI.15.86

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P433

http://www.w3.org/2001/XMLSchema#string

P478

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Xinyong Liu

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2015-12-08T00:00:00Z

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286313876

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26646727

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Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.

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P2860

P2860

Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P5875

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P5875

P698