Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.
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Mitochondrial Stat3, the Need for Design ThinkingThe consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domainTargeting SH2 domains in breast cancerSTAT3 inhibitors for cancer therapy: Have all roads been explored?A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft modelBrevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cellsThe anthelmintic drug niclosamide induces apoptosis, impairs metastasis and reduces immunosuppressive cells in breast cancer modelIdentification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validationSignal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agentDiscovery of monocarbonyl curcumin-BTP hybrids as STAT3 inhibitors for drug-sensitive and drug-resistant breast cancer therapy.Therapeutic modulators of STAT signalling for human diseasesHCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases.Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy.Involvement of the janus kinase/signal transducer and activator of transcription signaling pathway in multiple sclerosis and the animal model of experimental autoimmune encephalomyelitis.Identification of novel inhibitors that disrupt STAT3-DNA interaction from a γ-AApeptide OBOC combinatorial libraryThe oncogenic potential of human cytomegalovirus and breast cancer.Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumoursWithaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple MyelomaChanges in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization.Progress towards the development of SH2 domain inhibitors.Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in miceAberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor.HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer.Targeting survivin in cancer: novel drug development approaches.Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanismDevelopment of new N-Arylbenzamides as STAT3 Dimerization Inhibitors.Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemiaA novel small-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription 3.A Resveratrol Analogue Promotes ERKMAPK-Dependent Stat3 Serine and Tyrosine Phosphorylation Alterations and Antitumor Effects In Vitro against Human Tumor Cells.STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation.Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma.Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer.CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence.Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening.High Glucose-Mediated STAT3 Activation in Endometrial Cancer Is Inhibited by Metformin: Therapeutic Implications for Endometrial Cancer.Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model.Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors Suppress Human Glioma and Breast Cancer Phenotypes In Vitro and In Vivo.
P2860
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P2860
Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Orally bioavailable small-mole ...... st and lung cancer xenografts.
@ast
Orally bioavailable small-mole ...... st and lung cancer xenografts.
@en
type
label
Orally bioavailable small-mole ...... st and lung cancer xenografts.
@ast
Orally bioavailable small-mole ...... st and lung cancer xenografts.
@en
prefLabel
Orally bioavailable small-mole ...... st and lung cancer xenografts.
@ast
Orally bioavailable small-mole ...... st and lung cancer xenografts.
@en
P2093
P2860
P356
P1476
Orally bioavailable small-mole ...... st and lung cancer xenografts.
@en
P2093
Andrew T Namanja
Brent D G Page
David Paladino
James Turkson
Patrick T Gunning
Peibin Yue
Tianshu Li
Xiaolei Zhang
P2860
P304
P356
10.1073/PNAS.1121606109
P407
P577
2012-05-23T00:00:00Z