Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development - Wikidata - wikimedia - TriplyDB

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

http://www.wikidata.org/entity/Q36070647

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Synaptic Wnt/GSK3β Signaling Hub in Autism The study of psychiatric disease genes and drugs in zebrafish Neuronal migration abnormalities and its possible implications for schizophrenia Toward developmental models of psychiatric disorders in zebrafish DISC1: a key lead in studying cortical development and associated brain disorders Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice Wnt signaling networks in autism spectrum disorder and intellectual disability TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology Neurodevelopment in schizophrenia: the role of the wnt pathways.Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia.Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase.708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function.GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.Disc1 variation leads to specific alterations in adult neurogenesis.DISC1 Ser704Cys impacts thalamic-prefrontal connectivity.Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability.Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1 Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish.Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.DISC1 genetics, biology and psychiatric illness Utility and validity of DISC1 mouse models in biological psychiatry.Opposing actions of the synapse-associated protein of 97-kDa molecular weight (SAP97) and Disrupted in Schizophrenia 1 (DISC1) on Wnt/β-catenin signaling.The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function.Control of cortex development by ULK4, a rare risk gene for mental disorders including schizophrenia Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia.Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro.Neural stem cells: mechanisms and modeling.What does the developing brain tell us about neural diseases?Wnt signaling: role in Alzheimer disease and schizophrenia.Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia.Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia.Neurodegenerative aspects in vulnerability to schizophrenia spectrum disorders.Zebrafish as tools for drug discovery.Differences in cognitive impairment between schizophrenia and bipolar disorder: Considering the role of heterogeneity.Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue.

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P2860

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

http://www.wikidata.org/entity/Q36070647

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name

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

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Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

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type

label

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

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Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

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prefLabel

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

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Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

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Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

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Cillian King

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Gianluca De Rienzo

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Jon Madison

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Karun K Singh

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Laurel Drane

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Li-Huei Tsai

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Manuel Ferreira

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Pamela Sklar

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Zachary Flood

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P2860

Rare chromosomal deletions and duplications increase risk of schizophrenia

Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex

A beta-arrestin 2 signaling complex mediates lithium action on behavior

DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling

Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

Large recurrent microdeletions associated with schizophrenia

A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system

Disruption of two novel genes by a translocation co-segregating with schizophrenia

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