Fatal breathing dysfunction in a mouse model of Leigh syndrome
about
Oxygen regulation of breathing through an olfactory receptor activated by lactatePartial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage.Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviorsVocal development in dystonic rats.The physiological determinants of sudden infant death syndrome.PARP inhibition delays progression of mitochondrial encephalopathy in mice.Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I.Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration.Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse.Post-hypoxic recovery of respiratory rhythm generation is gender dependent.Mitochondrial Diseases Part I: mouse models of OXPHOS deficiencies caused by defects in respiratory complex subunits or assembly factors.Fertility-regulating Kiss1 neurons arise from hypothalamic POMC-expressing progenitors.Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies.Depressed Hypoxic and Hypercapnic Ventilatory Responses at Early Stage of Lethal Avian Influenza A Virus Infection in Mice.Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse BrainThe role of mitochondrially derived ATP in synaptic vesicle recyclingIncreased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia.Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome.Breathing challenges in Rett syndrome: lessons learned from humans and animal models.Central and peripheral factors contributing to obstructive sleep apneas.CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.Rapamycin enhances survival in a Drosophila model of mitochondrial disease.Cellular and animal models for mitochondrial complex I deficiency: a focus on the NDUFS4 subunit.Leigh syndrome: neuropathology and pathogenesis.AAV9-based gene therapy partially ameliorates the clinical phenotype of a mouse model of Leigh syndrome.Loss of Mitochondrial Ndufs4 in Striatal Medium Spiny Neurons Mediates Progressive Motor Impairment in a Mouse Model of Leigh Syndrome.Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease.Specific contributions of N-methyl-D-aspartate receptors in the dorsal striatum to cognitive flexibility.Acute oxygen sensing by the carotid body: from mitochondria to plasma membrane.Isoflurane anesthetic hypersensitivity and progressive respiratory depression in a mouse model with isolated mitochondrial complex I deficiency.An Essential Postdevelopmental Role for Lis1 in Mice.
P2860
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P2860
Fatal breathing dysfunction in a mouse model of Leigh syndrome
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Fatal breathing dysfunction in a mouse model of Leigh syndrome
@ast
Fatal breathing dysfunction in a mouse model of Leigh syndrome
@en
type
label
Fatal breathing dysfunction in a mouse model of Leigh syndrome
@ast
Fatal breathing dysfunction in a mouse model of Leigh syndrome
@en
prefLabel
Fatal breathing dysfunction in a mouse model of Leigh syndrome
@ast
Fatal breathing dysfunction in a mouse model of Leigh syndrome
@en
P2093
P2860
P50
P356
P1476
Fatal breathing dysfunction in a mouse model of Leigh syndrome
@en
P2093
Donghoon Lee
Henner Koch
Richard D Palmiter
Sebastien Zanella
P2860
P304
P356
10.1172/JCI62923
P407
P577
2012-06-01T00:00:00Z