about
Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy.Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome.Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice.Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I.Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments.Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.Fatal breathing dysfunction in a mouse model of Leigh syndromeAge modifies respiratory complex I and protein homeostasis in a muscle type-specific manner.Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.Synthesis and in vitro evaluation of new benzovesamicol analogues as potential imaging probes for the vesicular acetylcholine transporter.Mitochondrial complex III stabilizes complex I in the absence of NDUFS4 to provide partial activity
P50
Q30484862-AD635784-70CE-4AEB-AC21-438E32D87020Q33934412-DBAC5443-BC45-4EB8-A837-8DE2FA1FAF87Q34087645-77426FD4-F97D-4453-A1D2-E87E98696D80Q34389061-5D12411C-D7CF-4827-B697-13966095FD8AQ35878992-44313C68-B6FF-49B7-8B96-A6905719868AQ35898639-14111425-2C23-4ECE-974B-6023E1E87235Q36070987-BA057D8C-4A00-4EB8-AF42-AA923379B1B6Q36475207-EA583EAF-9064-48D2-B5E2-C153D2F015CAQ36937206-DD813479-9196-4AC7-B0C5-63323EF2658AQ37170429-1BEB6A18-DF82-45B2-A5F0-C83C12DD4989Q45226346-66152A82-9E9F-46D9-9083-24EAD502E917Q85030067-AF3E8CDB-F72D-4C89-BCDD-D6FB5FAFCBD9
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Shane Kruse
@ast
Shane Kruse
@en
Shane Kruse
@es
Shane Kruse
@nl
Shane Kruse
@sl
Шейн Крузе
@ru
type
label
Shane Kruse
@ast
Shane Kruse
@en
Shane Kruse
@es
Shane Kruse
@nl
Shane Kruse
@sl
Шейн Крузе
@ru
prefLabel
Shane Kruse
@ast
Shane Kruse
@en
Shane Kruse
@es
Shane Kruse
@nl
Shane Kruse
@sl
Шейн Крузе
@ru
P1053
L-8717-2014
P106
P21
P31
P3829
P496
0000-0001-6344-0650