A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis. - Wikidata - wikimedia - TriplyDB

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.

A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.

http://www.wikidata.org/entity/Q36088900

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The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis.Role of plasma matrix-metalloproteases (MMPs) and their polymorphisms (SNPs) in sepsis development and outcome in ICU patients.PAR1‑mediated c‑Jun activation promotes heat stress‑induced early stage apoptosis of human umbilical vein endothelial cells Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis.Mouse matrix metalloprotease-1a (Mmp1a) gives new insight into MMP function Heat stress-induced disruption of endothelial barrier function is via PAR1 signaling and suppressed by Xuebijing injection.Macrophage migration inhibitory factor induces vascular leakage via autophagy.Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar.Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger.Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo.Matrix metalloprotease-1a promotes tumorigenesis and metastasis.The MMP-1/PAR-1 Axis Enhances Proliferation and Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells Matrix metalloproteases and PAR1 activation.Noncanonical matrix metalloprotease-1-protease-activated receptor-1 signaling triggers vascular smooth muscle cell dedifferentiation and arterial stenosis.Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes through activation of protease activated receptor 1 Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature.Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation.Downregulation of MMP1 in MDS-derived mesenchymal stromal cells reduces the capacity to restrict MDS cell proliferation.Biased signaling of protease-activated receptors.Endothelial barrier dysfunction in septic shock.Proteinases, Their Extracellular Targets, and Inflammatory Signaling.Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis.Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).Impact of thrombosis on pulmonary endothelial injury and repair following sepsis.Targeting PAR1: Now What?Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics.Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study.The first MMP in sepsis.Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium.PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.MMP-1 overexpression selectively alters inhibition in D1 spiny projection neurons in the mouse nucleus accumbens core

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A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.

http://www.wikidata.org/entity/Q36088900

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A matrix metalloprotease-PAR1 ...... lammation and death in sepsis.

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A matrix metalloprotease-PAR1 ...... lammation and death in sepsis.

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A matrix metalloprotease-PAR1 ...... lammation and death in sepsis.

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A matrix metalloprotease-PAR1 ...... lammation and death in sepsis.

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A matrix metalloprotease-PAR1 ...... lammation and death in sepsis.

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EMBO Molecular Medicine

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A matrix metalloprotease-PAR1 ...... flammation and death in sepsis

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Anika Agarwal

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Athan Kuliopulos

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Caitlin Foley

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Karyn Austin

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Lidija Covic

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Nicole C Kaneider

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Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity

Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1

Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation

Efficacy and safety of recombinant human activated protein C for severe sepsis

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008

Development of monocytes, macrophages, and dendritic cells

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference

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