Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR - Wikidata - wikimedia - TriplyDB

Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR

Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR

http://www.wikidata.org/entity/Q36092657

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Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters.Folding and rescue of a cystic fibrosis transmembrane conductance regulator trafficking mutant identified using human-murine chimeric proteins Alteration of protein function by a silent polymorphism linked to tRNA abundance.The H-loop in the second nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator is required for efficient chloride channel closing Marked repression of CFTR mRNA in the transgenic Cftr(tm1kth) mouse model.Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.Human-mouse cystic fibrosis transmembrane conductance regulator (CFTR) chimeras identify regions that partially rescue CFTR-ΔF508 processing and alter its gating defect.Murine and human CFTR exhibit different sensitivities to CFTR potentiators.Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function Application of high-resolution single-channel recording to functional studies of cystic fibrosis mutants.State-dependent modulation of CFTR gating by pyrophosphate.Application of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanisms Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis.The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR.Altering intracellular pH reveals the kinetic basis of intraburst gating in the CFTR Cl- channel.Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants.Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel.Potentiators exert distinct effects on human, murine, and Xenopus CFTR.Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel Structural mechanisms of CFTR function and dysfunction.

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Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR

http://www.wikidata.org/entity/Q36092657

description

2007 nî lūn-bûn

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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Chimeric constructs endow the ...... gating behavior of murine CFTR

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Chimeric constructs endow the ...... gating behavior of murine CFTR

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Chimeric constructs endow the ...... gating behavior of murine CFTR

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Chimeric constructs endow the ...... gating behavior of murine CFTR

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Chimeric constructs endow the ...... gating behavior of murine CFTR

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A Christopher Boyd

http://www.w3.org/2001/XMLSchema#string

Ana Carina Da Paula

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Ann Doherty

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Brandon J Wainwright

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David N Sheppard

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Elizabeth S Dawson

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Heather Davidson

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Toby S Scott-Ward

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Zhiwei Cai

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P2860

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

Structure and function of the CFTR chloride channel

Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene.

ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.

Effect of ATP concentration on CFTR Cl- channels: a kinetic analysis of channel regulation

Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations.

Assembly of functional CFTR chloride channels.

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104

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David J. Porteous

Margarida D. Amaral

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