Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.
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Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16ANew and emerging targeted therapies for cystic fibrosisThyroid iodide efflux: a team effort?Kinetics of the Association/Dissociation Cycle of an ATP-binding Cassette Nucleotide-binding DomainCystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectivesIon transporting proteins of human bronchial epitheliumAllosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTRCurcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implicationsATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.A survey of detergents for the purification of stable, active human cystic fibrosis transmembrane conductance regulator (CFTR).Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epitheliaStructure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects.A single amino acid substitution in CFTR converts ATP to an inhibitory ligand.On the mechanism of CFTR inhibition by a thiazolidinone derivative.Specific and essential but not sufficient roles of LRRC8A in the activity of volume-sensitive outwardly rectifying anion channel (VSOR)Modulation of CFTR gating by permeant ions.Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells.Localizing a gate in CFTR.Biophysical characterisation of calumenin as a charged F508del-CFTR folding modulatorMutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function inCystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation.Molecular modelling and molecular dynamics of CFTR.Cystic fibrosis lung environment and Pseudomonas aeruginosa infection.CLC anion channel regulatory phosphorylation and conserved signal transduction domainsDemonstration of phosphoryl group transfer indicates that the ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) exhibits adenylate kinase activityRetinoid binding properties of nucleotide binding domain 1 of the Stargardt disease-associated ATP binding cassette (ABC) transporter, ABCA4.Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeationVx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle.Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsNonequilibrium gating of CFTR on an equilibrium theme.How Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).Application of high-resolution single-channel recording to functional studies of cystic fibrosis mutants.Application of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanismsCFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis.Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating.A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporterTargeting F508del-CFTR to develop rational new therapies for cystic fibrosis.
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P2860
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.
@en
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.
@nl
type
label
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.
@en
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.
@nl
prefLabel
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.
@en
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.
@nl
P2860
P1476
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.
@en
P2093
David N Sheppard
Tzyh-Chang Hwang
P2860
P304
P356
10.1113/JPHYSIOL.2009.171595
P407
P577
2009-03-30T00:00:00Z