Protective attenuated lentivirus immunization induces SIV-specific T cells in the genital tract of rhesus monkeys.
about
Alphavirus replicon-based adjuvants enhance the immunogenicity and effectiveness of Fluzone ® in rhesus macaquesLocation and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challengeCharacterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profilingCD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protectionHigh avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral functionAdhesion Molecules Associated with Female Genital Tract InfectionRecombinant Mycobacterium bovis BCG as an HIV vaccine vector.Localized populations of CD8 MHC class I tetramer SIV-specific T cells in lymphoid follicles and genital epitheliumHIV-1 vaccines: challenges and new perspectivesUse of nonhuman primate models to develop mucosal AIDS vaccines.Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo.Unpolarized release of vaccinia virus and HIV antigen by colchicine treatment enhances intranasal HIV antigen expression and mucosal humoral responses.Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaquesSIV-specific CD8+ T cells are enriched in female genital mucosa of rhesus macaques and express receptors for inflammatory chemokinesRetinoic acid as a vaccine adjuvant enhances CD8+ T cell response and mucosal protection from viral challenge.Vaginal type-II mucosa is an inductive site for primary CD8⁺ T-cell mucosal immunity.Characterization of an effective CTL response against HIV and SIV infections.Antiviral CD8+ T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89.6.Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge.Antiviral antibodies and T cells are present in the foreskin of simian immunodeficiency virus-infected rhesus macaques.Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV InfectionNew prospects for a preventive HIV-1 vaccine.Mucosal priming with a replicating-vaccinia virus-based vaccine elicits protective immunity to simian immunodeficiency virus challenge in rhesus monkeys.With minimal systemic T-cell expansion, CD8+ T Cells mediate protection of rhesus macaques immunized with attenuated simian-human immunodeficiency virus SHIV89.6 from vaginal challenge with simian immunodeficiency virus.Evaluation of recombinant influenza virus-simian immunodeficiency virus vaccines in macaques.Limited dissemination of pathogenic SIV after vaginal challenge of rhesus monkeys immunized with a live, attenuated lentivirusImmune quiescence: a model of protection against HIV infection.Innate immune control of nucleic acid-based vaccine immunogenicity.Chemokine-mediated immune responses in the female genital tract mucosa.Coming of age: reconstruction of heterosexual HIV-1 transmission in human ex vivo organ culture systems.Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases.High immune activation and abnormal expression of cytokines contribute to death of SHIV89.6-infected Chinese rhesus macaques.
P2860
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P2860
Protective attenuated lentivirus immunization induces SIV-specific T cells in the genital tract of rhesus monkeys.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Protective attenuated lentivir ...... nital tract of rhesus monkeys.
@ast
Protective attenuated lentivir ...... nital tract of rhesus monkeys.
@en
type
label
Protective attenuated lentivir ...... nital tract of rhesus monkeys.
@ast
Protective attenuated lentivir ...... nital tract of rhesus monkeys.
@en
prefLabel
Protective attenuated lentivir ...... nital tract of rhesus monkeys.
@ast
Protective attenuated lentivir ...... nital tract of rhesus monkeys.
@en
P2093
P2860
P356
P1433
P1476
Protective attenuated lentivir ...... enital tract of rhesus monkeys
@en
P2093
C J Miller
M B McChesney
T L Rourke
P2860
P2888
P304
P356
10.1038/MI.2008.6
P577
2008-03-05T00:00:00Z