Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration. - Wikidata - wikimedia - TriplyDB

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

http://www.wikidata.org/entity/Q36108255

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The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition Anti-apoptotic BCL-2 family proteins in acute neural injury Regulation of the intrinsic apoptosis pathway by reactive oxygen species A new view of the lethal apoptotic pore Mitochondria and mitophagy: the yin and yang of cell death control Mitochondrial apoptosis and BH3 mimetics A bifunctional protein regulates mitochondrial protein synthesis The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma Cell biology. Metabolic control of cell death Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation Differential Effects of β-Blockers, Angiotensin II Receptor Blockers, and a Novel AT2R Agonist NP-6A4 on Stress Response of Nutrient-Starved Cardiovascular Cells Energy metabolism regulated by HDAC inhibitor attenuates cardiac injury in hemorrhagic rat model.Arylazopyrazole AAP1742 inhibits CDKs and induces apoptosis in multiple myeloma cells via Mcl-1 downregulation.The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells.Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection Mcl-1 ubiquitination: unique regulation of an essential survival protein.Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice.Multiple functions of BCL-2 family proteins.HuR controls mitochondrial morphology through the regulation of BclxL translation.Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro MiR-29a promotes intestinal epithelial apoptosis in ulcerative colitis by down-regulating Mcl-1 Wnt modulates MCL1 to control cell survival in triple negative breast cancer.MCL1 enhances the survival of CD8+ memory T Cells after viral infection.Targeting mcl-1 for radiosensitization of pancreatic cancers.Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).Transcriptomic profiles of aging in purified human immune cells CHCHD2 inhibits apoptosis by interacting with Bcl-x L to regulate Bax activation.Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death.Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.Photoactivatable green fluorescent protein-based visualization and quantification of mitochondrial fusion and mitochondrial network complexity in living cells.Bruce Ames, phd, and Rhonda Patrick, phd: Discussing the Triage Concept and the Vitamin D-Serotonin Connection.Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain.Chidamide Inhibits Aerobic Metabolism to Induce Pancreatic Cancer Cell Growth Arrest by Promoting Mcl-1 Degradation Mcl-1 is a key regulator of the ovarian reserve Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death Delving deeper: MCL-1's contributions to normal and cancer biology.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia.Mcl-1 regulates effector and memory CD8 T-cell differentiation during acute viral infection.

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Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

http://www.wikidata.org/entity/Q36108255

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name

Anti-apoptotic MCL-1 localizes ...... ondrial fusion to respiration.

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Anti-apoptotic MCL-1 localizes ...... ondrial fusion to respiration.

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Anti-apoptotic MCL-1 localizes ...... ondrial fusion to respiration.

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Anti-apoptotic MCL-1 localizes ...... ondrial fusion to respiration.

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Nature Cell Biology

P1476

Anti-apoptotic MCL-1 localizes ...... ondrial fusion to respiration.

@en

P2093

Brian Koss

http://www.w3.org/2001/XMLSchema#string

Daniel P Stewart

http://www.w3.org/2001/XMLSchema#string

Jamshid Temirov

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John D Schuetz

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John Lynch

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Joseph T Opferman

http://www.w3.org/2001/XMLSchema#string

Madhavi Bathina

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Rhonda M Perciavalle

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Richard J Youle

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Sandra Milasta

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P2860

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

Brick by brick: metabolism and tumor cell growth

The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast.

Mitochondrial membrane potential is dependent on the oligomeric state of F1F0-ATP synthase supracomplexes.

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

Cell death: critical control points

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575-583

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10.1038/NCB2488

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6

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14

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Douglas R. Green

Megan M. Cleland

Stéphane Pelletier

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2012-04-29T00:00:00Z

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224867750

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P698

22544066

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P921

apoptotic process

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3401947

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