CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery. - Wikidata - wikimedia - TriplyDB

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery.

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery.

http://www.wikidata.org/entity/Q36112863

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Clinical development of gene therapy: results and lessons from recent successes Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging Protective and detrimental roles for regulatory T cells in a viral model for multiple sclerosis Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor Adoptive transfer of cytokine-induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice.Development of Gene Transfer for Induction of Antigen-specific Tolerance.Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses.Screening and identification of human ZnT8-specific single-chain variable fragment (scFv) from type 1 diabetes phage display library.Controlled release strategies for modulating immune responses to promote tissue regeneration Targeting Treg signaling for the treatment of autoimmune diseases The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance.Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases.Genetic Susceptibility to Multiple Sclerosis: The Role of FOXP3 Gene Polymorphism.T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases.Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease.The therapeutic potential of regulatory T cells for the treatment of autoimmune disease.Regulatory T cells: tolerance induction in solid organ transplantation.In vivo induction of regulatory T cells for immune tolerance in hemophilia.Stabilizing human regulatory T cells for tolerance inducing immunotherapy.Current status and regulatory perspective of chimeric antigen receptor-modified T cell therapeutics.CAR T-Cell Therapy: Progress and Prospects.Cell-Based Therapies with T Regulatory Cells.How antigen specificity directs regulatory T-cell function: self, foreign and engineered specificity.Regulatory T Cells: Central Concepts from Ontogeny to Therapy.Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.Engineered regulatory T cells coexpressing MHC class II:peptide complexes are efficient inhibitors of autoimmune T cell function and prevent the development of autoimmune arthritis.In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance.CARs: Synthetic Immunoreceptors for Cancer Therapy and Beyond.Antigen-specific immunotherapies in rheumatic diseases.The Role of the Ikaros Family of Transcription Factors in Regulatory T cell Development and Function.Expression and Function of the Cholinergic System in Immune Cells.Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells.From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance.Therapeutic application of T regulatory cells in composite tissue allotransplantation.Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells.Posttransplant chimeric antigen receptor therapy.Engineering therapeutic T cells to suppress alloimmune responses using TCRs, CARs, or BARs.

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P2860

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery.

http://www.wikidata.org/entity/Q36112863

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CAR/FoxP3-engineered T regulat ...... EAE upon intranasal delivery.

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Journal of Neuroinflammation

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Berith Nilsson

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Binfeng Lu

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Elena Piras

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Magnus Essand

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Moa Fransson

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Peetra U Magnusson

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Robert A Harris

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P2860

Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein

Control of regulatory T cell development by the transcription factor Foxp3

Artificial T-cell receptors.

Transport of drugs from the nasal cavity to the central nervous system.

Intranasal delivery of cells to the brain.

Human RORγt+ TH17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors

Regulatory T cells in the control of immune pathology.

Regulatory T cells: the physiology of autoreactivity in dominant tolerance and "quality control" of immune responses.

Regulatory CD4+ T cells and the control of autoimmune disease.

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

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9

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Eva B. Brittebo

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