Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor
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The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsDevelopment of selective agonists and antagonists of P2Y receptors.Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.Signalling and pharmacological properties of the P2Y receptor.UDP is a competitive antagonist at the human P2Y14 receptorP2Y nucleotide receptors: promise of therapeutic applicationsPyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modificationsDevelopment of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential.P2Y6 receptor-mediated proinflammatory signaling in human bronchial epithelia.4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor.G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactionsStructure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptorMolecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes.Probing GPCR structure: adenosine and P2Y nucleotide receptors.AMP-activated protein kinase as regulator of P2Y(6) receptor-induced insulin secretion in mouse pancreatic β-cellsSynthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.Thymidine 5'-O-monophosphorothioate induces HeLa cell migration by activation of the P2Y6 receptor.Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucoseQuantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.Radical-translocation intermediates and hurdling of pathway defects in "super-oxidized" (Mn(IV)/Fe(IV)) Chlamydia trachomatis ribonucleotide reductase.P2X and P2Y nucleotide receptors as targets in cardiovascular disease.Development of a comprehensive set of P2 receptor pharmacological research compoundsInhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo.Purinergic receptors regulate myogenic tone in cerebral parenchymal arterioles.Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors.Exploring the role of the 5-substituent for the intrinsic fluorescence of 5-aryl and 5-heteroaryl uracil nucleotides: a systematic study.Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y6 Receptor Agonists.Mining human genome for novel purinergic P2Y receptors: a sequence analysis and molecular modeling approach.
P2860
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P2860
Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor
description
2006 nî lūn-bûn
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2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Structure-activity relationshi ...... ues at the human P2Y6 receptor
@ast
Structure-activity relationshi ...... ues at the human P2Y6 receptor
@en
type
label
Structure-activity relationshi ...... ues at the human P2Y6 receptor
@ast
Structure-activity relationshi ...... ues at the human P2Y6 receptor
@en
prefLabel
Structure-activity relationshi ...... ues at the human P2Y6 receptor
@ast
Structure-activity relationshi ...... ues at the human P2Y6 receptor
@en
P2093
P2860
P356
P1476
Structure-activity relationshi ...... ues at the human P2Y6 receptor
@en
P2093
Christophe Mathé
Dae Hong Shin
Gilles Gosselin
Julien Gagneron
Kenneth A Jacobson
Pedro Besada
Savitri Maddileti
Stefano Costanzi
T Kendall Harden
P2860
P304
P356
10.1021/JM060485N
P407
P577
2006-09-01T00:00:00Z