Contact-dependent inhibition of EGFR signaling by Nf2/Merlin - Wikidata - wikimedia - TriplyDB

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

http://www.wikidata.org/entity/Q36118464

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A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP Cadherin signaling: keeping cells in touch Neurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.Regulation of G protein-coupled receptor function by Na+/H+ exchange regulatory factors E-cadherin's dark side: possible role in tumor progression Engineering cell-cell signaling NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor Toward precision medicine of breast cancer Epidermal growth factor signaling in transformed cells Hippo/YAP pathway for targeted therapy Molecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering study PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.Roles for E-cadherin cell surface regulation in cancer E-cadherin-mediated force transduction signals regulate global cell mechanics Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.Development of drug treatments for neurofibromatosis type 2-associated vestibular schwannoma.Neurofibromatosis type 2.Oncogenic role of Merlin/NF2 in glioblastoma.Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2.Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1 Merlin/ERM proteins establish cortical asymmetry and centrosome position.The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.Cell migration is regulated by platelet-derived growth factor receptor endocytosis Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling.Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients.Optimizing biologically targeted clinical trials for neurofibromatosis.Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas.Global profiling in vestibular schwannomas shows critical deregulation of microRNAs and upregulation in those included in chromosomal region 14q32.Microarray analysis of gene expression in vestibular schwannomas reveals SPP1/MET signaling pathway and androgen receptor deregulation.Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.Treatment of vestibular schwannoma cells with ErbB inhibitors

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P2860

Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

http://www.wikidata.org/entity/Q36118464

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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Journal of Cell Biology

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Contact-dependent inhibition of EGFR signaling by Nf2/Merlin

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Andrea I McClatchey

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Banumathi K Cole

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Ching-Hui Liu

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Dominique Lallemand

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Marcello Curto

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P2860

Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family

Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

Principles of tumor suppression

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin

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10.1083/JCB.200703010

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2064288

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