Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. - Wikidata - wikimedia - TriplyDB

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

http://www.wikidata.org/entity/Q36127992

about

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease Nuclear PI3K signaling in cell growth and tumorigenesis Phosphoinositides: tiny lipids with giant impact on cell regulation Phosphoinositides: Key modulators of energy metabolism Where is mTOR and what is it doing there?Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.Lysosomal physiology.Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression.Growing knowledge of the mTOR signaling network.Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.Exploring phosphatidylinositol 5-phosphate 4-kinase function.Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma.Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.Detection and manipulation of phosphoinositides.Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control.Target of rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress in Saccharomyces cerevisiae.The role of lipids in the control of autophagy Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.Unexpected severe consequences of Pikfyve deletion by aP2- or Aq-promoter-driven Cre expression for glucose homeostasis and mammary gland development.VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation.Classes of phosphoinositide 3-kinases at a glance.Roles for PI(3,5)P2 in nutrient sensing through TORC1.An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels.Regulation of autophagy by amino acids and MTOR-dependent signal transduction.PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.Target of rapamycin signaling mediates vacuolar fragmentation.PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics.Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides.

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Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

http://www.wikidata.org/entity/Q36127992

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年论文

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2012年论文

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Phosphatidylinositol 3,5-bisph ...... anistic target of rapamycin 1.

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Phosphatidylinositol 3,5-bisph ...... anistic target of rapamycin 1.

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Phosphatidylinositol 3,5-bisph ...... anistic target of rapamycin 1.

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MBC.E11-12-1034

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Molecular Biology of the Cell

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Phosphatidylinositol 3,5-bisph ...... anistic target of rapamycin 1.

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Alan R Saltiel

http://www.w3.org/2001/XMLSchema#string

Dave Bridges

http://www.w3.org/2001/XMLSchema#string

Jing-Tyan Ma

http://www.w3.org/2001/XMLSchema#string

Ken Inoki

http://www.w3.org/2001/XMLSchema#string

Lois S Weisman

http://www.w3.org/2001/XMLSchema#string

Sujin Park

http://www.w3.org/2001/XMLSchema#string

P2860

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans

The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice

Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology

Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5

Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.

The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover

Phosphoinositides in cell regulation and membrane dynamics

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2955-2962

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10.1091/MBC.E11-12-1034

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15

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23

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2012-06-13T00:00:00Z

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225305548

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22696681

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3408421

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