Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation.
about
Experimental therapies and ongoing clinical trials to slow down progression of ADPKDHDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesisHyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.A mechanism linking Id2-TGFβ crosstalk to reversible adaptive plasticity in neuroblastomaTreatment of chronic kidney diseases with histone deacetylase inhibitors.TNFα signaling regulates cystic epithelial cell proliferation through Akt/mTOR and ERK/MAPK/Cdk2 mediated Id2 signalingTherapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional levelMacrophage migration inhibitory factor promotes cyst growth in polycystic kidney diseaseEpigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer.Little fish, big catch: zebrafish as a model for kidney diseaseInhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney diseaseHDAC inhibitors in kidney development and disease.Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts.New treatments for autosomal dominant polycystic kidney diseaseDevelopmental signaling: does it bridge the gap between cilia dysfunction and renal cystogenesis?New options in the treatment of autosomal dominant polycystic kidney disease.The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease.Epigenetic Regulation in Cystogenesis.Emerging Therapies for Childhood Polycystic Kidney Disease.Profiling of miRNAs and target genes related to cystogenesis in ADPKD mouse models.Therapeutic effects of histone deacetylase inhibitors on kidney disease.The combination of an HDAC6 inhibitor and a somatostatin receptor agonist synergistically reduces hepato-renal cystogenesis in an animal model of polycystic liver disease.Cux1 promotes cell proliferation and polycystic kidney disease progression in an ADPKD mouse model.Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells.
P2860
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P2860
Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Inhibition of histone deacetyl ...... epithelial cell proliferation.
@ast
Inhibition of histone deacetyl ...... epithelial cell proliferation.
@en
type
label
Inhibition of histone deacetyl ...... epithelial cell proliferation.
@ast
Inhibition of histone deacetyl ...... epithelial cell proliferation.
@en
prefLabel
Inhibition of histone deacetyl ...... epithelial cell proliferation.
@ast
Inhibition of histone deacetyl ...... epithelial cell proliferation.
@en
P2093
P2860
P356
P1433
P1476
Inhibition of histone deacetyl ...... epithelial cell proliferation.
@en
P2093
Brenda Magenheimer
James P Calvet
Lucy X Fan
Xiaogang Li
Xinjian Li
P2860
P2888
P356
10.1038/KI.2011.296
P407
P577
2011-09-07T00:00:00Z
P5875
P6179
1011555085