An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. - Wikidata - wikimedia - TriplyDB

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene.

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene.

http://www.wikidata.org/entity/Q36163092

about

Gene therapy for lipid disorders The adenovirus genome contributes to the structural stability of the virion Gene therapy: light is finally in the tunnel An adenovirus type 5 (Ad5) amplicon-based packaging cell line for production of high-capacity helper-independent deltaE1-E2-E3-E4 Ad5 vectors.Gutless adenovirus: last-generation adenovirus for gene therapy Comparison of osteogenic potentials of human rat BMP4 and BMP6 gene therapy using [E1-] and [E1-,E2b-] adenoviral vectors.Methods, potentials, and limitations of gene delivery to regenerate central nervous system cells Production of adenovirus vectors and their use as a delivery system for influenza vaccines.Human gene therapy and imaging in neurological diseases.Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model.Adenoviral vector immunity: its implications and circumvention strategies.Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis.Generation of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3.Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors.DNA as therapeutics; an update.Gene therapy in the CNS.Altering the Ad5 packaging domain affects the maturation of the Ad particles.Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector A novel system for the production of fully deleted adenovirus vectors that does not require helper adenovirus.Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders Improvements in adenoviral vector technology: overcoming barriers for gene therapy.Regulatable atrial natriuretic peptide gene therapy for hypertension.Molecular advances to treat cancer of the brain.Recombinant adenovirus-mediated overexpression of 3β-hydroxysteroid-Δ24 reductase.Gene therapy in wound repair and regeneration.The future of leptin and leptin analogues in the treatment of obesity.Gene therapy: development of immunostimulatory treatments for cancer.The promise and potential hazards of adenovirus gene therapy.From gene transfer to gene therapy in lysosomal storage diseases affecting the central nervous system.Viral-based modelling and correction of neurodegenerative diseases by RNA interference.Gene therapy for haemophilia.Neonatal helper-dependent adenoviral vector gene therapy mediates correction of hemophilia A and tolerance to human factor VIII Current strategies and future directions for eluding adenoviral vector immunity Optimization of the helper-dependent adenovirus system for production and potency in vivo.Cre levels limit packaging signal excision efficiency in the Cre/loxP helper-dependent adenoviral vector system.Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector.Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.Subretinal gene delivery using helper-dependent adenoviral vectors.Implications of the innate immune response to adenovirus and adenoviral vectors.Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy.

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P2860

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene.

http://www.wikidata.org/entity/Q36163092

description

1998 nî lūn-bûn

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1998年论文

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name

An adenoviral vector deleted f ...... ression of a leptin transgene.

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An adenoviral vector deleted f ...... ression of a leptin transgene.

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An adenoviral vector deleted f ...... ression of a leptin transgene.

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An adenoviral vector deleted f ...... ression of a leptin transgene.

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An adenoviral vector deleted f ...... ression of a leptin transgene.

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An adenoviral vector deleted f ...... ression of a leptin transgene.

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Proceedings of the National Academy of Sciences of the United States of America

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An adenoviral vector deleted f ...... ression of a leptin transgene.

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Allen H

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Bett AJ

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Caskey CT

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Franlin L

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Graham FL

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Gu M

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Kochanek S

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Lin J

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Morsy MA

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Motzel S

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P2860

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

Weight-reducing effects of the plasma protein encoded by the obese gene

Effects of the obese gene product on body weight regulation in ob/ob mice

Efficient adenoviral-mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytes.

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks.

Rescue, propagation, and partial purification of a helper virus-dependent adenovirus vector

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo.

A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging.

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7866-7871

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14

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