Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model.
about
Animal models of hemophiliaDevelopment and use of DNA archives at veterinary teaching hospitals to investigate the genetic basis of disease in dogsComparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia AAdenoviral Vectors for Hemophilia Gene TherapyLeukocyte count affects expression of reference genes in canine whole blood samples.MyD88-dependent silencing of transgene expression during the innate and adaptive immune response to helper-dependent adenovirus.Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.Study of the efficacy, biodistribution, and safety profile of therapeutic gutless adenovirus vectors as a prelude to a phase I clinical trial for glioblastoma.Recombinant canine B-domain-deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model.Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B.Efficacy and safety of long-term prophylaxis in severe hemophilia A dogs following liver gene therapy using AAV vectors.Helper-dependent adenoviral vectors for liver-directed gene therapy.Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency.In vivo expansion of regulatory T cells with IL-2/IL-2 mAb complexes prevents anti-factor VIII immune responses in hemophilia A mice treated with factor VIII plasmid-mediated gene therapy.NOD2 signaling contributes to the innate immune response against helper-dependent adenovirus vectors independently of MyD88 in vivo.Genomic analysis of Sleeping Beauty transposon integration in human somatic cells.Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trialDifferential type I interferon-dependent transgene silencing of helper-dependent adenoviral vs. adeno-associated viral vectors in vivo.Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors.Animal models of hemophilia and related bleeding disorders.Transgene expression up to 7 years in nonhuman primates following hepatic transduction with helper-dependent adenoviral vectors.Successful treatment of canine hemophilia by continuous expression of canine FVIIa.Gene therapy with helper-dependent adenoviral vectors: current advances and future perspectives.Gene and cell therapy based treatment strategies for inflammatory bowel diseases.Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies.Gene therapy for immune tolerance induction in hemophilia with inhibitors.Gene therapy with helper-dependent adenoviral vectors: lessons from studies in large animal models.Adenovirus late-phase infection is controlled by a novel L4 promoter.A rapid protocol for construction and production of high-capacity adenoviral vectors.Adenovirus-Vectored Broadly Neutralizing Antibodies Directed Against gp120 Prevent Human Immunodeficiency Virus Type 1 Acquisition in Humanized Mice.Advances in Overcoming Immune Responses following Hemophilia Gene Therapy.Rescue administration of a helper-dependent adenovirus vector with long-term efficacy in dogs with glycogen storage disease type Ia.Toward gene therapy for hemophilia A with novel adenoviral vectors: successes and limitations in canine models.Feasibility of Applying Helper-Dependent Adenoviral Vectors for Cancer Immunotherapy.
P2860
Q27012571-9D44224C-091D-4F58-AAEB-F5D448F0062EQ30856794-F1CECE7E-11A2-446D-8358-5F43F1E1B7C1Q33688429-8B44B0B8-9C5C-4664-A012-C86D149F5607Q33690648-E043C23E-E380-43EE-B011-DB8045EB2074Q33814994-5A63AECB-DB3B-41E8-ABEC-2DF4E85037D8Q33832157-DD844DA8-9B05-4B6F-BDFA-34711FAC2B84Q33881920-35FEBBE4-6428-4E42-B123-B536FA6ED026Q34012284-A64B7776-986A-4887-A96B-829D24BFD4AFQ34078730-BD208237-3CC3-421E-B20E-76C5326B11DAQ34343757-5BEF09F7-2D67-4209-B402-DF6C64C14105Q34621668-E80DBCDE-FDF7-428E-920D-BD90080B26AEQ34982825-64205F37-2C4A-4B6E-B541-429E20750658Q35006603-7BFBE1DE-7EB6-417E-BF0D-98148E648979Q35144444-F4D4AF17-2FE1-4284-82F8-3C93240654D7Q35226121-E78A582A-2938-40A2-A43C-7514CAE62241Q35413268-33DA4EA4-6274-4C41-B669-36002309AA1AQ36534329-35707316-D440-44CE-933E-165D6E955476Q36740271-821925BA-900D-4865-9793-B92D0F144B96Q37089746-5D21C63B-B316-4529-AB48-C824F7777E29Q37091290-844452EC-FD8F-4AC4-808B-6803BA71473BQ37102059-44E736E0-301D-4673-9AB5-9E93D601FC62Q37162830-B40A1A83-FE98-4D33-ABB2-AB94C1CD369AQ37945218-4662DC3F-ADCE-488F-B04D-E645B07D13FEQ37969759-8DF4E89D-3183-4D02-AD06-EB3024BC9A6FQ38754256-5988FEB6-F698-4A68-A6CE-D9698D4874DDQ38803022-5F1A4FA9-BA0C-47CD-83F8-31332E8AAE33Q39358889-9DF11766-991D-4E0A-864F-6AE69AE323B4Q39707314-983852B6-BDF0-44BA-AD97-0E1D7963DAE5Q39859960-74D544E6-EE99-4B0C-A48A-D8A7C1ABB778Q41249890-EE5FD8F0-4361-458B-85E9-A04DF64EF3E6Q42209182-25FE8BD1-C80A-41A0-A87D-EE4C997E58D4Q44199828-CA38DFE3-6185-4449-B7FA-D392C2F7A85AQ45858373-44D62313-CE91-46AA-8303-56905A9A8F8AQ51847569-84EF65F4-9004-4F97-BC61-975E428E78E3
P2860
Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Helper-dependent adenoviral ge ...... the canine hemophilia A model.
@ast
Helper-dependent adenoviral ge ...... the canine hemophilia A model.
@en
type
label
Helper-dependent adenoviral ge ...... the canine hemophilia A model.
@ast
Helper-dependent adenoviral ge ...... the canine hemophilia A model.
@en
prefLabel
Helper-dependent adenoviral ge ...... the canine hemophilia A model.
@ast
Helper-dependent adenoviral ge ...... the canine hemophilia A model.
@en
P2093
P2860
P921
P1476
Helper-dependent adenoviral ge ...... the canine hemophilia A model.
@en
P2093
D J Palmer
K Ubhayakar
M P Seiler
T C Nichols
T K Bertin
W M McCORMACK
P2860
P304
P356
10.1111/J.1538-7836.2006.01901.X
P577
2006-06-01T00:00:00Z