Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice
about
The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytesAnimal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside-a Comprehensive ReviewA soft coral-derived compound, 11-epi-sinulariolide acetate suppresses inflammatory response and bone destruction in adjuvant-induced arthritisThe value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritisCD4+CD25+ regulatory T cells in autoimmune arthritis.Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis.Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant miceDendritic cells under investigation in autoimmune disease.Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression.Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritisSpontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis.Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β.Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alphaA point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expressionSystemic inhibition of canonical Notch signaling results in sustained callus inflammation and alters multiple phases of fracture healing.S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin.Treatment of mice with the neutrophil-depleting antibody RB6-8C5 results in early development of experimental lyme arthritis via the recruitment of Gr-1- polymorphonuclear leukocyte-like cells.Lessons from animal models of arthritis over the past decade.TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.The degree of CD4+ T cell autoreactivity determines cellular pathways underlying inflammatory arthritisThe significance of non-human primates as preclinical models of human arthritic disease.Old and new therapeutics for Rheumatoid Arthritis: in vivo models and drug development.Arthritis models: usefulness and interpretation.IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oilCytokines and cellular interactions in inflammatory synovitis.IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1.Gene and Protein Expression Profiles in a Mouse Model of Collagen-Induced Arthritis.The expression of matrix metalloproteinases and their inhibitors in corneal fibroblasts by alarmins from necrotic corneal epithelial cells.IL-34- and M-CSF-induced macrophages switch memory T cells into Th17 cells via membrane IL-1α.MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages.IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouseWhat Have We Learned about the Pathogenesis of Rheumatoid Arthritis from TNF-Targeted Therapy?
P2860
Q21195661-7A8D4ED9-E880-4620-B1BC-6B47850F6B8BQ26774874-EB8C1D71-09E8-402C-A134-A1472E9594C3Q28487935-1603FB13-EBF3-4B01-8B8D-F314674F8434Q33458893-41E1F111-94A8-4AAF-AC53-A2C7AD6E69BCQ34012863-E27AB1B4-74D2-4040-A079-1EBCD6767F6FQ34084020-B20C168C-24E2-403A-BD8C-AD0D7D4037CAQ35083269-459955DF-8E05-4B47-A24B-D2C97FCC1245Q35086727-120975B2-584F-4A9C-B98B-6B69C1FD4A59Q35518745-5C85E824-DDBB-4123-9069-26B81B0F2128Q35617594-1BB15B71-9FF2-443D-84EC-9BC554915915Q35946169-7BAA3AD3-E4C3-4112-8916-A73594F91BC1Q36213688-043D5B60-E3AD-4A6C-8665-36F671DF35E9Q36246023-EAFC40A8-D9FE-4B3E-9811-FC00EB592FF4Q36371158-5DE3FA52-4E3E-44C6-913A-1C08F4FC05FFQ36586991-3659AAE1-0723-49AC-A2F4-D32D512DFB8EQ36981367-B96A49C6-B68E-41F3-8F14-724CCBD1DBC1Q37187378-AA7B2382-77BB-408D-B364-4D16C8C6CE82Q37521592-84586EF0-0886-44C9-AC5A-51FDB15038F3Q37619719-78C03998-8F9B-47E4-AEEC-61B320D1043CQ37625825-BFAEFBF7-01DD-46B5-8D9C-DC9967BE17FEQ37681930-8FFB3104-0310-46D6-82E7-13E45389E228Q38088311-5BE2D9EC-21D2-43E5-9206-DA2805054216Q38697262-7FD846D8-7743-4275-AC1B-512DEB9D4BA3Q38872112-F3AD083B-A477-4C1C-A63C-1D96941D880EQ39274974-CD1A2A56-6192-48A4-8EFC-8A086FD36F7DQ39946607-DC35BA04-B13D-4A1F-A823-201996F975FAQ47399044-29ADA0DF-C209-4F9D-A8A7-B18370BF2B8BQ49227179-2FF7A24A-1527-4263-ABCA-BBA56331AA75Q50221142-880636F8-9AC4-4C57-BD56-53C00D991B67Q50761288-87AC0CFA-DCA1-4B53-B150-DD4BB6C7E4A8Q54454015-FB523CDC-1C10-4378-AA06-21629BE9F813Q58562869-DBA157BE-26CA-4D92-AA3E-0ED9B3763095Q58691977-88DC8D8A-346D-4A64-B30B-FA44560706E0
P2860
Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice
@ast
Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice
@en
type
label
Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice
@ast
Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice
@en
prefLabel
Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice
@ast
Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice
@en
P2093
P2860
P356
P1476
Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice
@en
P2093
H Takaishi
K Fujikawa
P2860
P304
P356
10.1172/JCI11530
P407
P577
2001-05-01T00:00:00Z