A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. - Wikidata - wikimedia - TriplyDB

A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.

A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.

http://www.wikidata.org/entity/Q36371158

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c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130 Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis Altered signalling thresholds in T lymphocytes cause autoimmune arthritis Negative regulation of cytokine signaling and immune responses by SOCS proteins The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation Revisiting the 1986 molecular cloning of interleukin 6 The pathological and physiological roles of IL-6 amplifier activation Pathophysiological roles for IL-18 in inflammatory arthritis A systems model of phosphorylation for inflammatory signaling events Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation The reverse-direction method links mass experimental data to human diseases.Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice.The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis Mechanism of attenuation of leptin signaling under chronic ligand stimulation.Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.gp130 at the nexus of inflammation, autoimmunity, and cancer.SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir Cadherin-11 regulates fibroblast inflammation IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis Characterization of a novel and spontaneous mouse model of inflammatory arthritis.Regulation of TLR signaling and inflammation by SOCS family proteins.Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow Cells of the synovium in rheumatoid arthritis. T lymphocytes.A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases.Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment.Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis.Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.Fas (CD95)-related apoptosis and rheumatoid arthritis.Cytokine signal regulation and autoimmune disorders.STAT3: a potential therapeutic target in dendritic cells for the induction of transplant tolerance.IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells.Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis.Suppression of cytokine signaling: the SOCS perspective.Anti-angiogenic effect of total saponins of Rhizoma Dioscorea nipponica on collagen induced-arthritis in rats.Developments in the scientific understanding of rheumatoid arthritis.Lessons from animal models of arthritis over the past decade.Interpreting mixed signals: the cell's cytokine conundrum.

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P2860

A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.

http://www.wikidata.org/entity/Q36371158

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Daisuke Kamimura

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Hideto Ikushima

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Hideyuki Kobayashi

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Katsuhiko Ishihara

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Seiichi Hirota

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Sung-Joo Park

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Takuya Ohtani

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Toru Atsumi

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Toshio Hirano

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Yukihiko Kitamura

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P2860

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis

Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)

Role of cytokines in rheumatoid arthritis

Programmed cell death and extrathymic reduction of Vbeta8+ CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B.

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.

Regulation of activation-induced cell death of mature T-lymphocyte populations.

Tolerance and autoimmunity.

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196

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12370259

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2194024

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