Mu opioid receptor activation of ERK1/2 is GRK3 and arrestin dependent in striatal neurons
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Ser/ Thr residues at α3/β5 loop of Gαs are important in morphine-induced adenylyl cyclase sensitization but not mitogen-activated protein kinase phosphorylationBeta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transductionEndogenous opiates and behavior: 2006Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.The protective signaling of metabotropic glutamate receptor 1 Is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation.Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosisOpioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment.Change in functional selectivity of morphine with the development of antinociceptive tolerance.Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding.Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.Arrestin development: emerging roles for beta-arrestins in developmental signaling pathwaysAnalysis of opioid efficacy, tolerance, addiction and dependence from cell culture to humanInhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways.Opioid receptor internalization contributes to dermorphin-mediated antinociceptionSerine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling.Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.Morphine-induced MOR-1X and ASF/SF2 Expressions Are Independent of Transcriptional Regulation: Implications for MOR-1X SignalingMolecular mechanisms of opioid receptor-dependent signaling and behavior.Activation of mu opioid receptors in the striatum differentially augments methamphetamine-induced gene expression and enhances stereotypic behavior.Characterization of methadone as a β-arrestin-biased μ-opioid receptor agonist.Extracellular signal-regulated kinase 1/2 activation counteracts morphine tolerance in the periaqueductal gray of the ratNeuronal extracellular signal-regulated kinase (ERK) activity as marker and mediator of alcohol and opioid dependence.Custom-designed proteins as novel therapeutic tools? The case of arrestins.Structural determinants of arrestin functionsβ-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.Enhanced phosphorylation-independent arrestins and gene therapy.Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors.Effect of acute fentanyl treatment on synaptic plasticity in the hippocampal CA1 region in rats.Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.Differential Effects of Oxycodone, Hydrocodone, and Morphine on Activation Levels of Signaling Molecules.Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines
P2860
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P2860
Mu opioid receptor activation of ERK1/2 is GRK3 and arrestin dependent in striatal neurons
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Mu opioid receptor activation ...... dependent in striatal neurons
@ast
Mu opioid receptor activation ...... dependent in striatal neurons
@en
type
label
Mu opioid receptor activation ...... dependent in striatal neurons
@ast
Mu opioid receptor activation ...... dependent in striatal neurons
@en
prefLabel
Mu opioid receptor activation ...... dependent in striatal neurons
@ast
Mu opioid receptor activation ...... dependent in striatal neurons
@en
P2093
P2860
P356
P1476
Mu opioid receptor activation ...... dependent in striatal neurons
@en
P2093
Charles Chavkin
Janet D Lowe
Tara A Macey
P2860
P304
34515-34524
P356
10.1074/JBC.M604278200
P407
P577
2006-09-18T00:00:00Z