Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis

Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis

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http://www.wikidata.org/entity/Q36186289
Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin.Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance.TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes.Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β-cell insulin secretion during inflammation.SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia.Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on β-Cell Function.TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.Beta-cell hubs maintain Ca oscillations in human and mouse islet simulations
P2860

Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis

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http://www.wikidata.org/entity/Q36186289
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2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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name
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
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Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
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type
label
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@ast
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@en
prefLabel
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@ast
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@en
P1433
P1476
P2093
P2860
P304
P31
P356
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P433
P478
P577
P698
P921
P932
P356
P1433
P1476
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P921
P932