Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion
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Repression of a potassium channel by nuclear hormone receptor and TGF-β signaling modulates insulin signaling in Caenorhabditis elegansDeletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.Kv2.1 cell surface clusters are insertion platforms for ion channel delivery to the plasma membranePancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.Inhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals.Systematic Synergy of Glucose and GLP-1 to Stimulate Insulin Secretion Revealed by Quantitative Phosphoproteomics.Evidence for presence and functional effects of Kv1.1 channels in β-cells: general survey and results from mceph/mceph mice.Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors.An exploratory study of the association between KCNB1 rs1051295 and type 2 diabetes and its related traits in Chinese Han population.A SUMO-Phospho tag team for wrestling with potassium channel gating.Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus.The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cellsIntermediate conductance Ca2+-activated K+ channels modulate human placental trophoblast syncytializationPhospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cube.Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in miceGroup VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signalingPaternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1cSUMO downregulates GLP-1-stimulated cAMP generation and insulin secretionBursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose HomeostasisDistinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal NeuronsCell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells.Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null miceIon channels and regulation of insulin secretion in human β-cells: a computational systems analysisSP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways.Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.Impairment of pancreatic β-cell function by chronic intermittent hypoxiaEnhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells.A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cellsVoltage-gated potassium channels as therapeutic targets.β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.Signal integration at the level of ion channel and exocytotic function in pancreatic β-cells.Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.In silico prediction of novel therapeutic targets using gene-disease association data.Role of outer-pore residue Y380 in U-type inactivation of KV2.1 channels.The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance.Pancreatic β-cell prosurvival effects of the incretin hormones involve post-translational modification of Kv2.1 delayed rectifier channels.
P2860
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P2860
Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion
description
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im September 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/09/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/09/01)
@nl
наукова стаття, опублікована у вересні 2007
@uk
مقالة علمية (نشرت في سبتمبر 2007)
@ar
name
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@ast
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@en
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@nl
type
label
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@ast
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@en
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@nl
prefLabel
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@ast
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@en
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@nl
P2093
P2860
P921
P3181
P1433
P1476
Kv2.1 ablation alters glucose- ...... y, enhancing insulin secretion
@en
P2093
Andrey Kuznetsov
Carina E. Ammälä
David A. Jacobson
James P. Lopez
Louis H. Philipson
Shera Kash
P2860
P304
P3181
P356
10.1016/J.CMET.2007.07.010
P577
2007-09-01T00:00:00Z