Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.
about
Tyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocketIP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in miceKIT receptor gain-of-function in hematopoiesis enhances stem cell self-renewal and promotes progenitor cell expansion.Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors.High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.The spleen microenvironment influences disease transformation in a mouse model of KITD816V-dependent myeloproliferative neoplasm.ETV1-Positive Cells Give Rise to BRAFV600E -Mutant Gastrointestinal Stromal Tumors.Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.
P2860
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P2860
Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Imatinib resistance and microc ...... astrointestinal stromal tumor.
@ast
Imatinib resistance and microc ...... astrointestinal stromal tumor.
@en
type
label
Imatinib resistance and microc ...... astrointestinal stromal tumor.
@ast
Imatinib resistance and microc ...... astrointestinal stromal tumor.
@en
prefLabel
Imatinib resistance and microc ...... astrointestinal stromal tumor.
@ast
Imatinib resistance and microc ...... astrointestinal stromal tumor.
@en
P2093
P2860
P356
P1476
Imatinib resistance and microc ...... astrointestinal stromal tumor.
@en
P2093
Benedikt Bosbach
Cristina R Antonescu
Darren R Veach
Ferdinand Rossi
Gunhild Sommer
Jae-Hung Shieh
Joseph M Scandura
Katia Manova-Todorova
Malcolm A S Moore
Peter Besmer
P2860
P304
P356
10.1073/PNAS.1115240109
P407
P577
2012-05-31T00:00:00Z