A structural basis for the biochemical behavior of activation-induced deoxycytidine deaminase class-switch recombination-defective hyper-IgM-2 mutants
about
Etoposide induces nuclear re-localisation of AIDActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.AID and Apobec3G haphazard deamination and mutational diversityHigh-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.Overlapping hotspots in CDRs are critical sites for V region diversificationIndividual substitution mutations in the AID C terminus that ablate IgH class switch recombination.Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine.Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability.Functional requirements of AID's higher order structures and their interaction with RNA-binding proteinsStructural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversificationA biochemical analysis linking APOBEC3A to disparate HIV-1 restriction and skin cancerActivation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombinationCyclin-dependent kinases regulate Ig class switching by controlling access of AID to the switch region.First report of the Hyper-IgM syndrome Registry of the Latin American Society for Immunodeficiencies: novel mutations, unique infections, and outcomes.Increased serum IgM, immunodeficiency, and autoimmunity: A clinical series.Biochemical Regulatory Features of Activation-Induced Cytidine Deaminase Remain Conserved from Lampreys to Humans.A licensing step links AID to transcription elongation for mutagenesis in B cells.
P2860
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P2860
A structural basis for the biochemical behavior of activation-induced deoxycytidine deaminase class-switch recombination-defective hyper-IgM-2 mutants
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
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2012年论文
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2012年论文
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name
A structural basis for the bio ...... -defective hyper-IgM-2 mutants
@ast
A structural basis for the bio ...... -defective hyper-IgM-2 mutants
@en
type
label
A structural basis for the bio ...... -defective hyper-IgM-2 mutants
@ast
A structural basis for the bio ...... -defective hyper-IgM-2 mutants
@en
prefLabel
A structural basis for the bio ...... -defective hyper-IgM-2 mutants
@ast
A structural basis for the bio ...... -defective hyper-IgM-2 mutants
@en
P2093
P2860
P356
P1476
A structural basis for the bio ...... -defective hyper-IgM-2 mutants
@en
P2093
Courtney Prochnow
Myron F Goodman
Phuong Pham
Xiaojiang S Chen
Yunxiang Mu
P2860
P304
28007-28016
P356
10.1074/JBC.M112.370189
P407
P577
2012-06-19T00:00:00Z