Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination
about
IgH chain class switch recombination: mechanism and regulationConsecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminaseIndividual substitution mutations in the AID C terminus that ablate IgH class switch recombination.Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID.Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance.Functional requirements of AID's higher order structures and their interaction with RNA-binding proteinsThe SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation.UNG protects B cells from AID-induced telomere loss.Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations.Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites.Increased serum IgM, immunodeficiency, and autoimmunity: A clinical series.AID Biology: A pathological and clinical perspective.Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination.Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes.A licensing step links AID to transcription elongation for mutagenesis in B cells.Transient AID expression for in situ mutagenesis with improved cellular fitness.AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice
P2860
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P2860
Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 03 March 2014
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Activation induced deaminase C ...... ing class switch recombination
@en
Activation induced deaminase C ...... ng class switch recombination.
@nl
type
label
Activation induced deaminase C ...... ing class switch recombination
@en
Activation induced deaminase C ...... ng class switch recombination.
@nl
prefLabel
Activation induced deaminase C ...... ing class switch recombination
@en
Activation induced deaminase C ...... ng class switch recombination.
@nl
P2093
P2860
P50
P356
P1476
Activation induced deaminase C ...... ing class switch recombination
@en
P2093
Anil K Eranki
Anne-Marie Patenaude
Astrid Zahn
Elena M Cortizas
Heather Fifield
Kohsuke Imai
Mani Larijani
Paul Foster
Ramiro E Verdun
P2860
P304
P356
10.1073/PNAS.1320486111
P407
P577
2014-03-03T00:00:00Z