The N-terminal extension of cardiac troponin T stabilizes the blocked state of cardiac thin filament
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Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutationsHypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation.In situ time-resolved FRET reveals effects of sarcomere length on cardiac thin-filament activation.Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of nemaline myopathyLength-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation.The functional effect of dilated cardiomyopathy mutation (R144W) in mouse cardiac troponin T is differently affected by α- and β-myosin heavy chain isoformsTuning the calcium sensitivity of cardiac muscleRat cardiac troponin T mutation (F72L)-mediated impact on thin filament cooperativity is divergently modulated by α- and β-myosin heavy chain isoforms.ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease.Cardiac Myosin Binding Protein-C Phosphorylation Modulates Myofilament Length-Dependent ActivationThe tropomyosin binding region of cardiac troponin T modulates crossbridge recruitment dynamics in rat cardiac muscle fibers.Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomereInterplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by α- and β-Myosin Heavy Chain Isoforms.Interplay between the overlapping ends of tropomyosin and the N terminus of cardiac troponin T affects tropomyosin states on actinDivergent effects of α- and β-myosin heavy chain isoforms on the N terminus of rat cardiac troponin T.Instability in the central region of tropomyosin modulates the function of its overlapping ends.Dilated Cardiomyopathy Mutation (R134W) in Mouse Cardiac Troponin T Induces Greater Contractile Deficits against α-Myosin Heavy Chain than against β-Myosin Heavy Chain.Cardiac myosin binding protein-C Ser302 phosphorylation regulates cardiac β-adrenergic reserveA study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.L71F mutation in rat cardiac troponin T augments crossbridge recruitment and detachment dynamics against α-myosin heavy chain, but not against β-myosin heavy chain.Historical perspective on heart function: the Frank-Starling Law.Interplay between the effects of a Protein Kinase C phosphomimic (T204E) and a dilated cardiomyopathy mutation (K211Δ or R206W) in rat cardiac troponin T blunts the magnitude of muscle length-mediated crossbridge recruitment against the β-myosin heaThe effect of cardiomyopathy mutation (R97L) in mouse cardiac troponin T on the muscle length-mediated recruitment of crossbridges is modified divergently by α- and β-myosin heavy chain.50 years of allosteric interactions: the twists and turns of the models.Omecamtiv Mecarbil Abolishes Length-Mediated Increase in Guinea Pig Cardiac Myofiber Ca2+ Sensitivity.Hypertrophic cardiomyopathy mutation in cardiac troponin T (R95H) attenuates length-dependent activation in guinea pig cardiac muscle fibers.Cardiomyopathy mutation (F88L) in troponin T abolishes length dependency of myofilament Ca sensitivity
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P2860
The N-terminal extension of cardiac troponin T stabilizes the blocked state of cardiac thin filament
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The N-terminal extension of ca ...... state of cardiac thin filament
@ast
The N-terminal extension of ca ...... state of cardiac thin filament
@en
type
label
The N-terminal extension of ca ...... state of cardiac thin filament
@ast
The N-terminal extension of ca ...... state of cardiac thin filament
@en
prefLabel
The N-terminal extension of ca ...... state of cardiac thin filament
@ast
The N-terminal extension of ca ...... state of cardiac thin filament
@en
P2093
P2860
P1433
P1476
The N-terminal extension of ca ...... state of cardiac thin filament
@en
P2093
Murali Chandra
Ranganath Mamidi
Sampath K Gollapudi
Sri Lakshmi Mallampalli
P2860
P304
P356
10.1016/J.BPJ.2012.07.035
P407
P577
2012-09-01T00:00:00Z