Ion-controlled conformational dynamics in the outward-open transition from an occluded state of LeuT.
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Visualizing functional motions of membrane transporters with molecular dynamics simulationsSpontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusA conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na+ coupling.Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT ProteomicellesConformational Changes in Two Inter-Helical Loops of Mhp1 Membrane Transporter.Hydrophobic plug functions as a gate in voltage-gated proton channels.Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporterStructural dynamics of the monoamine transporter homolog LeuT from accelerated conformational sampling and channel analysisConformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1.Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.Metadynamics simulations reveal a Na+ independent exiting path of galactose for the inward-facing conformation of vSGLTMicroseconds simulations reveal a new sodium-binding site and the mechanism of sodium-coupled substrate uptake by LeuTThe molecular mechanism of ion-dependent gating in secondary transporters.Mapping the gating and permeation pathways in the voltage-gated proton channel Hv1.Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium SymportersComputational characterization of structural dynamics underlying function in active membrane transporters.Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops.The Environment Shapes the Inner Vestibule of LeuT.AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems.Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter HomologChloride binding site of neurotransmitter sodium symporters.Computational approaches to detect allosteric pathways in transmembrane molecular machines.Coupled global and local changes direct substrate translocation by neurotransmitter-sodium symporter ortholog LeuT.The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site.Na+ coordination at the Na2 site of the Na+/I- symporter.Functional identification and characterization of sodium binding sites in Na symporters.The two Na+ sites in the human serotonin transporter play distinct roles in the ion coupling and electrogenicity of transportA Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter.How does water pass through a sugar transporter?Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer.The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications.Ion channels and ion selectivity.MHC class II complexes sample intermediate states along the peptide exchange pathway.Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290Structure and Dynamics Study of LeuT Using the Markov State Model and Perturbation Response Scanning Reveals Distinct Ion Induced Conformational States.Insights on Na(+) binding and conformational dynamics in multidrug and toxic compound extrusion transporter NorM.Mechanism of Substrate Translocation in an Alternating Access Transporter.
P2860
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P2860
Ion-controlled conformational dynamics in the outward-open transition from an occluded state of LeuT.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Ion-controlled conformational ...... rom an occluded state of LeuT.
@ast
Ion-controlled conformational ...... rom an occluded state of LeuT.
@en
type
label
Ion-controlled conformational ...... rom an occluded state of LeuT.
@ast
Ion-controlled conformational ...... rom an occluded state of LeuT.
@en
prefLabel
Ion-controlled conformational ...... rom an occluded state of LeuT.
@ast
Ion-controlled conformational ...... rom an occluded state of LeuT.
@en
P2093
P2860
P1433
P1476
Ion-controlled conformational ...... rom an occluded state of LeuT.
@en
P2093
Chunfeng Zhao
Harel Weinstein
Luis Gracia
Sebastian Stolzenberg
Sergei Noskov
P2860
P304
P356
10.1016/J.BPJ.2012.07.044
P407
P577
2012-09-01T00:00:00Z