Mutations in alpha- and beta-tubulin affect spindle formation in Chinese hamster ovary cells
about
Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs.A ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferationMegakaryocyte lineage-specific class VI β-tubulin suppresses microtubule dynamics, fragments microtubules, and blocks cell division.Class V β-tubulin alters dynamic instability and stimulates microtubule detachment from centrosomes.Transfer and amplification of a mutant beta-tubulin gene results in colcemid dependence: use of the transformant to demonstrate regulation of beta-tubulin subunit levels by protein degradation.Cell line-specific differences in the control of cell cycle progression in the absence of mitosisMitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistanceA microtubule-dependent zone of active RhoA during cleavage plane specificationCellular regulation of microtubule organization.Molecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance.Random mutagenesis of β-tubulin defines a set of dispersed mutations that confer paclitaxel resistance.Paclitaxel resistance by random mutagenesis of α-tubulin.Heightened sensitivity to paclitaxel in Class IVa beta-tubulin-transfected cells is lost as expression increases.
P2860
Q24633520-B526C36A-06C5-4B4F-9FDA-B6871E558443Q28512163-228128E8-ABE0-48EF-A951-AE03B750BE2DQ30428045-74848C33-06BE-4F24-85B0-D0F96199C385Q30431870-FC8B482D-8F95-4D28-A68F-AEE8852D3F6EQ30449962-8C0A32ED-7F82-4BFE-8341-3ABECD2313F1Q33922516-7D06504E-4009-47CE-B16B-BE309920C2DFQ35379041-078135A6-F008-45EE-8B67-104795D31087Q36320722-630FE2DF-A3F1-4DFC-B7F8-4759A5D1260DQ36510214-6CF99E8B-7A80-47B2-9240-F5D51ECBAC5FQ37176441-90116C34-D699-43C6-8193-75E309338546Q39336478-A057E6CF-919C-4FE8-A1F4-0B91E0427850Q44561268-1B242891-21DD-4A0B-A6A3-FBBC70761CA6Q51796128-63981497-9596-4061-BFBA-52EE41C92166
P2860
Mutations in alpha- and beta-tubulin affect spindle formation in Chinese hamster ovary cells
description
1983 nî lūn-bûn
@nan
1983年の論文
@ja
1983年論文
@yue
1983年論文
@zh-hant
1983年論文
@zh-hk
1983年論文
@zh-mo
1983年論文
@zh-tw
1983年论文
@wuu
1983年论文
@zh
1983年论文
@zh-cn
name
Mutations in alpha- and beta-t ...... in Chinese hamster ovary cells
@ast
Mutations in alpha- and beta-t ...... in Chinese hamster ovary cells
@en
type
label
Mutations in alpha- and beta-t ...... in Chinese hamster ovary cells
@ast
Mutations in alpha- and beta-t ...... in Chinese hamster ovary cells
@en
prefLabel
Mutations in alpha- and beta-t ...... in Chinese hamster ovary cells
@ast
Mutations in alpha- and beta-t ...... in Chinese hamster ovary cells
@en
P2093
P2860
P356
P1476
Mutations in alpha- and beta-t ...... in Chinese hamster ovary cells
@en
P2093
P2860
P304
P356
10.1083/JCB.97.4.1055
P407
P577
1983-10-01T00:00:00Z